H3BMF4 · H3BMF4_HUMAN
- ProteinProtein spinster homolog 1
- GeneSPNS1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids573 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Catalytic activity
- 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine(out) + H+(out) = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine(in) + H+(in)
- 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine(out) + H+(out) = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine(in) + H+(in)
- a 1-acyl-sn-glycero-3-phosphocholine(out) + H+(out) = a 1-acyl-sn-glycero-3-phosphocholine(in) + H+(in)
- a 1-acyl-sn-glycero-3-phosphoethanolamine(out) + H+(out) = a 1-acyl-sn-glycero-3-phosphoethanolamine(in) + H+(in)
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | lysosomal membrane | |
Molecular Function | transmembrane transporter activity |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameProtein spinster homolog 1
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionH3BMF4
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Lysosome membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 103-119 | Helical | ||||
Sequence: SALIVAVLCYINLLNYM | ||||||
Transmembrane | 144-164 | Helical | ||||
Sequence: LIQTVFISSYMVLAPVFGYLG | ||||||
Transmembrane | 171-190 | Helical | ||||
Sequence: YLMCGGIAFWSLVTLGSSFI | ||||||
Transmembrane | 210-226 | Helical | ||||
Sequence: ASYSTIAPTLIADLFVA | ||||||
Transmembrane | 233-251 | Helical | ||||
Sequence: LSIFYFAIPVGSGLGYIAG | ||||||
Transmembrane | 263-283 | Helical | ||||
Sequence: WALRVTPGLGVVAVLLLFLVV | ||||||
Transmembrane | 318-339 | Helical | ||||
Sequence: FVLSSLGFTAVAFVTGSLALWA | ||||||
Transmembrane | 368-389 | Helical | ||||
Sequence: LIFGLITCLTGVLGVGLGVEIS | ||||||
Transmembrane | 401-420 | Helical | ||||
Sequence: PLVCATGLLGSAPFLFLSLA | ||||||
Transmembrane | 426-456 | Helical | ||||
Sequence: IVATYIFIFIGETLLSMNWAIVADILLYVVI | ||||||
Transmembrane | 468-487 | Helical | ||||
Sequence: IVLSHLLGDAGSPYLIGLIS | ||||||
Transmembrane | 507-530 | Helical | ||||
Sequence: FSLMLCAFVGALGGAAFLGTAIFI |
Keywords
- Cellular component
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 646 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
PTM/Processing
Features
Showing features for modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Modified residue (large scale data) | 69 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 550 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 551 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 563 | PRIDE | Phosphoserine | ||||
Sequence: S |
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-94 | Disordered | ||||
Sequence: MTGFKQHGGCRGAAPGLSDSKCSGLLPRVGSSVGPERGRARPPGTMAGSDTAPFLSQADDPDDGPVPGTPGLPGSTGNPKSEEPEVPDQEGLQR | ||||||
Domain | 106-534 | Major facilitator superfamily (MFS) profile | ||||
Sequence: IVAVLCYINLLNYMDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGEHFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWHWALRVTPGLGVVAVLLLFLVVREPPRGAVERHSDLPPLNPTSWWADLRALARNPSFVLSSLGFTAVAFVTGSLALWAPAFLLRSRVVLGETPPCLPGDSCSSSDSLIFGLITCLTGVLGVGLGVEISRRLRHSNPRADPLVCATGLLGSAPFLFLSLACARGSIVATYIFIFIGETLLSMNWAIVADILLYVVIPTRRSTAEAFQIVLSHLLGDAGSPYLIGLISDRLRRNWPPSFLSEFRALQFSLMLCAFVGALGGAAFLGTAIFIEADR |
Sequence similarities
Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length573
- Mass (Da)61,106
- Last updated2012-04-18 v1
- Checksum9522431CB0D625D1
Computationally mapped potential isoform sequences
There are 6 potential isoforms mapped to this entry
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC109460 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471267 EMBL· GenBank· DDBJ | EAW52016.1 EMBL· GenBank· DDBJ | Genomic DNA |