Disruption of <i>Hars2</i> in Cochlear Hair Cells Causes Progressive Mitochondrial Dysfunction and Hearing Loss in Mice.Xu P., Wang L., Peng H., Liu H., Liu H., Yuan Q., Lin Y., Xu J., Pang X.[...], Yang T.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 103170PubMedEurope PMCFront Cell Neurosci 15:804345-804345 (2021)Mapped to11
Severe Inflammatory Reactions in Mice Expressing a GFI1<sup>P2A</sup> Mutant Defective in Binding to the Histone Demethylase KDM1A (LSD1).Fraszczak J., Arman K.M., Lacroix M., Vadnais C., Gaboury L., Moroy T.View abstractAnnotationSevere Inflammatory Reactions in Mice Expressing a GFI1(P2A) Mutant Defective in Binding to the Histone Demethylase KDM1A (LSD1).CategoriesFunction, Phenotypes & VariantsSourceGeneRif: 14581, MGI: 103170PubMedEurope PMCJ Immunol 207:1599-1615 (2021)Mapped to8
RIPK1 activates distinct gasdermins in macrophages and neutrophils upon pathogen blockade of innate immune signaling.Chen K.W., Demarco B., Ramos S., Heilig R., Goris M., Grayczyk J.P., Assenmacher C.A., Radaelli E., Joannas L.D.[...], Broz P.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 103170PubMedEurope PMCProc Natl Acad Sci U S A 118:e2101189118-e2101189118 (2021)Mapped to21
EMX2-GPR156-Galphai reverses hair cell orientation in mechanosensory epithelia.Kindt K.S., Akturk A., Jarysta A., Day M., Beirl A., Flonard M., Tarchini B.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 103170PubMedEurope PMCNat. Commun. 12:2861-2861 (2021)Cited in2Mapped to99+
C1ql1 is expressed in adult outer hair cells of the cochlea in a tonotopic gradient.Biswas J., Pijewski R.S., Makol R., Miramontes T.G., Thompson B.L., Kresic L.C., Burghard A.L., Oliver D.L., Martinelli D.C.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 103170PubMedEurope PMCPLoS One 16:e0251412-e0251412 (2021)Mapped to14
Mouse models of neutropenia reveal progenitor-stage-specific defects.Muench D.E., Olsson A., Ferchen K., Pham G., Serafin R.A., Chutipongtanate S., Dwivedi P., Song B., Hay S.[...], Grimes H.L.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 103170PubMedEurope PMCNature 582:109-114 (2020)Mapped to18
PKHD1L1 is a coat protein of hair-cell stereocilia and is required for normal hearing.Wu X., Ivanchenko M.V., Al Jandal H., Cicconet M., Indzhykulian A.A., Corey D.P.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 103170PubMedEurope PMCNat. Commun. 10:3801-3801 (2019)Cited in1Mapped to10
Deletion of Brg1 causes stereocilia bundle fusion and cuticular plate loss in vestibular hair cells.Jin Y., Gao X., Fu X., Li S., Sun X., Gao J.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 103170PubMedEurope PMCHear Res 377:247-259 (2019)Mapped to25
LSD1 inhibition by tranylcypromine derivatives interferes with GFI1- mediated repression of PU.1 target genes and induces differentiation in AML.Barth J., Abou-El-Ardat K., Dalic D., Kurrle N., Maier A.M., Mohr S., Schutte J., Vassen L., Greve G.[...], Berg T.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 103170PubMedEurope PMCLeukemia 33:1411-1426 (2019)Mapped to13
<i>Growth Factor-Independent 1</i> Is a Tumor Suppressor Gene in Colorectal Cancer.Chen M.S., Lo Y.H., Chen X., Williams C.S., Donnelly J.M., Criss Z.K., Patel S., Butkus J.M., Dubrulle J.[...], Shroyer N.F.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 103170PubMedEurope PMCMol Cancer Res 17:697-708 (2019)Mapped to23
CTCF is required for maintenance of auditory hair cells and hearing function in the mouse cochlea.Ma J.H., Kim H.P., Bok J., Shin J.O.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 103170PubMedEurope PMCBiochem Biophys Res Commun 503:2646-2652 (2018)Mapped to13
Neutrophils enhance early Trypanosoma brucei infection onset.Caljon G., Mabille D., Stijlemans B., De Trez C., Mazzone M., Tacchini-Cottier F., Malissen M., Van Ginderachter J.A., Magez S.[...], Van Den Abbeele J.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 103170PubMedEurope PMCSci Rep 8:11203-11203 (2018)Mapped to10
Reduced expression but not deficiency of GFI1 causes a fatal myeloproliferative disease in mice.Fraszczak J., Vadnais C., Rashkovan M., Ross J., Beauchemin H., Chen R., Grapton D., Khandanpour C., Moroy T.View abstractAnnotationLow Gfi1 expression is associated with myeloid leukemia and predisposes to fatal myeloproliferative disease.CategoriesFunction, Phenotypes & VariantsSourceGeneRif: 14581, MGI: 103170PubMedEurope PMCLeukemia 33:110-121 (2019)Mapped to22
Loss of murine Gfi1 causes neutropenia and induces osteoporosis depending on the pathogen load and systemic inflammation.Geissler S., Textor M., Stumpp S., Seitz S., Lekaj A., Brunk S., Klaassen S., Schinke T., Klein C.[...], Kuhnisch J.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 103170PubMedEurope PMCPLoS One 13:e0198510-e0198510 (2018)Mapped to8
GFI1 is required for <i>RUNX1/ETO</i> positive acute myeloid leukemia.Marneth A.E., Botezatu L., Hones J.M., Israel J.C.L., Schutte J., Vassen L., Lams R.F., Bergevoet S.M., Groothuis L.[...], Khandanpour C.CategoriesFunction, Phenotypes & VariantsSourceMGI: 103170PubMedEurope PMCHaematologica 103:e395-e399 (2018)Mapped to26
Codeficiency of Lysosomal Mucolipins 3 and 1 in Cochlear Hair Cells Diminishes Outer Hair Cell Longevity and Accelerates Age-Related Hearing Loss.Wiwatpanit T., Remis N.N., Ahmad A., Zhou Y., Clancy J.C., Cheatham M.A., Garcia-Anoveros J.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 103170PubMedEurope PMCJ Neurosci 38:3177-3189 (2018)Mapped to18
Exocyst Complex Member EXOC5 Is Required for Survival of Hair Cells and Spiral Ganglion Neurons and Maintenance of Hearing.Lee B., Baek J.I., Min H., Bae S.H., Moon K., Kim M.A., Kim Y.R., Fogelgren B., Lipschutz J.H.[...], Kim U.K.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 103170PubMedEurope PMCMol Neurobiol 55:6518-6532 (2018)Mapped to13
Enforced GFI1 expression impedes human and murine leukemic cell growth.Hones J.M., Thivakaran A., Botezatu L., Patnana P., Castro S.V.D.C., Al-Matary Y.S., Schutte J., Fischer K.B.I., Vassen L.[...], Khandanpour C.View abstractAnnotationThese results suggest that increasing GFI1 level in leukemic cells with low GFI1 expression level could be a therapeutic approach.CategoriesFunction, Phenotypes & VariantsSourceGeneRif: 14581, MGI: 103170PubMedEurope PMCSci Rep 7:15720-15720 (2017)Mapped to11
Innate Immune Basis for Rift Valley Fever Susceptibility in Mouse Models.Lathan R., Simon-Chazottes D., Jouvion G., Godon O., Malissen M., Flamand M., Bruhns P., Panthier J.J.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 103170PubMedEurope PMCSci Rep 7:7096-7096 (2017)Mapped to8
Megakaryocytes compensate for Kit insufficiency in murine arthritis.Cunin P., Penke L.R., Thon J.N., Monach P.A., Jones T., Chang M.H., Chen M.M., Melki I., Lacroix S.[...], Nigrovic P.A.View abstractCategoryPhenotypes & VariantsSourceMGI: 103170PubMedEurope PMCJ Clin Invest 127:1714-1724 (2017)Mapped to40
Gfi1<sup>Cre</sup> mice have early onset progressive hearing loss and induce recombination in numerous inner ear non-hair cells.Matern M., Vijayakumar S., Margulies Z., Milon B., Song Y., Elkon R., Zhang X., Jones S.M., Hertzano R.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 103170PubMedEurope PMCSci Rep 7:42079-42079 (2017)Mapped to8
AMPK promotes osteogenesis and inhibits adipogenesis through AMPK-Gfi1-OPN axis.Wang Y.G., Qu X.H., Yang Y., Han X.G., Wang L., Qiao H., Fan Q.M., Tang T.T., Dai K.R.View abstractAnnotationAMPK was sufficient to stimulate osteogenesis of MC3T3-E1 cells and inhibit adipogenesis of 3T3-L1 cells through the AMPK-Gfi1-OPN axis.CategoriesFunction, Phenotypes & VariantsSourceGeneRif: 14581PubMedEurope PMCCell Signal 28:1270-1282 (2016)Mapped to19
c-Jun N-Terminal Phosphorylation: Biomarker for Cellular Stress Rather than Cell Death in the Injured Cochlea.Anttonen T., Herranen A., Virkkala J., Kirjavainen A., Elomaa P., Laos M., Liang X., Ylikoski J., Behrens A., Pirvola U.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 103170PubMedEurope PMCeNeuro 3:ENEURO.0047-16.2016 (2016)Mapped to14
Hair-Cell Mechanotransduction Persists in TRP Channel Knockout Mice.Wu X., Indzhykulian A.A., Niksch P.D., Webber R.M., Garcia-Gonzalez M., Watnick T., Zhou J., Vollrath M.A., Corey D.P.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 103170PubMedEurope PMCPLoS One 11:e0155577-e0155577 (2016)Mapped to19
Activated notch causes deafness by promoting a supporting cell phenotype in developing auditory hair cells.Savoy-Burke G., Gilels F.A., Pan W., Pratt D., Que J., Gan L., White P.M., Kiernan A.E.View abstractCategoriesFunction, Expression, Phenotypes & VariantsSourceMGI: 103170PubMedEurope PMCPLoS One 9:e108160-e108160 (2014)Mapped to8