An MMTV integration site maps near the distal end of mouse chromosome 11.Rajan L., Dudley J.P.CategoriesFunction, SequencesSourceMGI: 95832PubMedEurope PMCMamm Genome 8:295-296 (1997)Mapped to39
Macrophage-fibroblast JAK/STAT dependent crosstalk promotes liver metastatic outgrowth in pancreatic cancer.Raymant M., Astuti Y., Alvaro-Espinosa L., Green D., Quaranta V., Bellomo G., Glenn M., Chandran-Gorner V., Palmer D.H.[...], Schmid M.C.View abstractCategoryFunctionSourceMGI: 95832PubMedEurope PMCNat Commun 15:3593-3593 (2024)Mapped to25
Regulation of muscle hypertrophy through granulin: Relayed communication among mesenchymal progenitors, macrophages, and satellite cells.Zhang L., Saito H., Higashimoto T., Kaji T., Nakamura A., Iwamori K., Nagano R., Motooka D., Okuzaki D.[...], Fukada S.I.View abstractCategoryFunctionSourceMGI: 95832PubMedEurope PMCCell Rep 43:114052-114052 (2024)Mapped to33
PhagoStat a scalable and interpretable end to end framework for efficient quantification of cell phagocytosis in neurodegenerative disease studies.Ounissi M., Latouche M., Racoceanu D.View abstractCategoryFunctionSourceMGI: 95832PubMedEurope PMCSci Rep 14:6482-6482 (2024)Mapped to21
Progranulin deficiency attenuates tubulointerstitial injury in a mouse unilateral ureteral obstruction model.Adachi E., Murakoshi M., Shibata T., Shimozawa K., Sakuma H., Kishida C., Gohda T., Suzuki Y.View abstractCategoryFunctionSourceMGI: 95832PubMedEurope PMCExp Anim 73:293-301 (2024)Mapped to18
Reduced progranulin increases tau and alpha-synuclein inclusions and alters mouse tauopathy phenotypes via glucocerebrosidase.Takahashi H., Bhagwagar S., Nies S.H., Ye H., Han X., Chiasseu M.T., Wang G., Mackenzie I.R., Strittmatter S.M.View abstractCategoryFunctionSourceMGI: 95832PubMedEurope PMCNat Commun 15:1434-1434 (2024)Mapped to18
Genetic determinants of micronucleus formation in vivo.Adams D.J., Barlas B., McIntyre R.E., Salguero I., van der Weyden L., Barros A., Vicente J.R., Karimpour N., Haider A.[...], White J.K.View abstractCategoryFunctionSourceMGI: 95832PubMedEurope PMCNature 627:130-136 (2024)Mapped to99+
Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons.Hasan S., Fernandopulle M.S., Humble S.W., Frankenfield A.M., Li H., Prestil R., Johnson K.R., Ryan B.J., Wade-Martins R.[...], Hao L.View abstractCategoryFunctionSourceMGI: 95832PubMedEurope PMCMol Neurodegener 18:87-87 (2023)Mapped to18
SorCS2 binds progranulin to regulate motor neuron development.Thomasen P.B., Salasova A., Kjaer-Sorensen K., Woloszczukova L., Lavicky J., Login H., Tranberg-Jensen J., Almeida S., Beel S.[...], Nykjaer A.View abstractCategoryFunctionSourceMGI: 95832PubMedEurope PMCCell Rep 42:113333-113333 (2023)Mapped to75
Progranulin deficiency exacerbates cardiac remodeling after myocardial infarction.Sasaki T., Kuse Y., Nakamura S., Shimazawa M., Hara H.View abstractCategoryFunctionSourceMGI: 95832PubMedEurope PMCFASEB Bioadv 5:395-411 (2023)Mapped to18
Progranulin Maintains Blood Pressure and Vascular Tone Dependent on EphrinA2 and Sortilin1 Receptors and Endothelial Nitric Oxide Synthase Activation.Bruder-Nascimento A., Awata W.M.C., Alves J.V., Singh S., Costa R.M., Bruder-Nascimento T.View abstractCategoryFunctionSourceMGI: 95832PubMedEurope PMCJ Am Heart Assoc 12:e030353-e030353 (2023)Mapped to18
AAV-<i>GRN</i> partially corrects motor deficits and ALS/FTLD-related pathology in <i>Tmem106b</i><sup><i>-/-</i></sup><i>Grn</i><sup><i>-/-</i></sup> mice.Feng T., Minevich G., Liu P., Qin H.X., Wozniak G., Pham J., Pham K., Korgaonkar A., Kurnellas M.[...], Hu F.View abstractCategoryFunctionSourceMGI: 95832PubMedEurope PMCiScience 26:107247-107247 (2023)Mapped to23
Lack of a protective effect of the Tmem106b "protective SNP" in the Grn knockout mouse model for frontotemporal lobar degeneration.Cabron A.S., Borgmeyer U., Richter J., Peisker H., Gutbrod K., Dormann P., Capell A., Damme M.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 95832PubMedEurope PMCActa Neuropathol Commun 11:21-21 (2023)Mapped to23
Progranulin loss results in sex-dependent dysregulation of the peripheral and central immune system.Houser M.C., Uriarte Huarte O., Wallings R.L., Keating C.E., MacPherson K.P., Herrick M.K., Kannarkat G.T., Kelly S.D., Chang J.[...], Tansey M.G.View abstractCategoriesFunction, ExpressionSourceMGI: 95832PubMedEurope PMCFront Immunol 13:1056417-1056417 (2022)Mapped to18
Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis.Boland S., Swarup S., Ambaw Y.A., Malia P.C., Richards R.C., Fischer A.W., Singh S., Aggarwal G., Spina S.[...], Farese R.V. Jr.View abstractCategoryFunctionSourceMGI: 95832PubMedEurope PMCNat Commun 13:5924-5924 (2022)Mapped to18
Progranulin aggravates lethal Candida albicans sepsis by regulating inflammatory response and antifungal immunity.Liu J., Lai X., Yu R., Ding H., Bai H., Yang Z., Yin Y., Xu F., Cao J.View abstractCategoryFunctionSourceMGI: 95832PubMedEurope PMCPLoS Pathog 18:e1010873-e1010873 (2022)Mapped to39
Progranulin-derived granulin E and lysosome membrane protein CD68 interact to reciprocally regulate their protein homeostasis.Santos M.N., Paushter D.H., Zhang T., Wu X., Feng T., Lou J., Du H., Becker S.M., Fragoza R.[...], Hu F.View abstractCategoriesFunction, Subcellular LocationSourceMGI: 95832PubMedEurope PMCJ Biol Chem 298:102348-102348 (2022)Mapped to22
Analysis of the Biomarkers for Neurodegenerative Diseases in Aged Progranulin Deficient Mice.Zhao X., Hasan S., Liou B., Lin Y., Sun Y., Liu C.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 95832PubMedEurope PMCInt J Mol Sci 23:629-629 (2022)Mapped to18
Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency.Reifschneider A., Robinson S., van Lengerich B., Gnorich J., Logan T., Heindl S., Vogt M.A., Weidinger E., Riedl L.[...], Haass C.View abstractCategoryFunctionSourceMGI: 95832PubMedEurope PMCEMBO J 41:e109108-e109108 (2022)Mapped to20
Retinal Degeneration and Microglial Dynamics in Mature Progranulin- Deficient Mice.Takahashi K., Nakamura S., Shimazawa M., Hara H.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 95832PubMedEurope PMCInt J Mol Sci 22:11557-11557 (2021)Mapped to18
Microglia regulate brain progranulin levels through the endocytosis/lysosomal pathway.Dong T., Tejwani L., Jung Y., Kokubu H., Luttik K., Driessen T.M., Lim J.View abstractCategoriesFunction, ExpressionSourceMGI: 95832PubMedEurope PMCJCI Insight 6:e136147-e136147 (2021)Mapped to28
Spreading of Alzheimer tau seeds is enhanced by aging and template matching with limited impact of amyloid-beta.Nies S.H., Takahashi H., Herber C.S., Huttner A., Chase A., Strittmatter S.M.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 95832PubMedEurope PMCJ Biol Chem 297:101159-101159 (2021)Mapped to80
Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic.Logan T., Simon M.J., Rana A., Cherf G.M., Srivastava A., Davis S.S., Low R.L.Y., Chiu C.L., Fang M.[...], Di Paolo G.View abstractCategoryFunctionSourceMGI: 95832PubMedEurope PMCCell 184:4651-4668.e25 (2021)Mapped to23
Progranulin deficiency in Iba-1<sup>+</sup> myeloid cells exacerbates choroidal neovascularization by perturbation of lysosomal function and abnormal inflammation.Takahashi K., Nakamura S., Otsu W., Shimazawa M., Hara H.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 95832PubMedEurope PMCJ Neuroinflammation 18:164-164 (2021)Mapped to18
DNA damage in embryonic neural stem cell determines FTLDs' fate via early- stage neuronal necrosis.Homma H., Tanaka H., Jin M., Jin X., Huang Y., Yoshioka Y., Bertens C.J., Tsumaki K., Kondo K.[...], Okazawa H.View abstractCategoryFunctionSourceMGI: 95832PubMedEurope PMCLife Sci Alliance 4:e202101022-e202101022 (2021)Mapped to47