H2QKZ8 · H2QKZ8_PANTR
- ProteinCarbonyl reductase (NADPH)
- GeneCBR1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids277 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
Catalytic activity
- H+ + NADPH + S-nitrosoglutathione = NADP+ + S-(hydroxysulfenamide)glutathione
- H+ + menadione + NADPH = menadiol + NADP+
- NADP+ + prostaglandin E2 = 15-oxoprostaglandin E2 + H+ + NADPHThis reaction proceeds in the forward direction.
- NADP+ + prostaglandin F2alpha = 15-oxoprostaglandin F2alpha + H+ + NADPHThis reaction proceeds in the forward direction.
- corticosterone + H+ + NADPH = 20beta-dihydrocorticosterone + NADP+This reaction proceeds in the forward direction.
- cortisol + H+ + NADPH = 20beta-dihydrocortisol + NADP+This reaction proceeds in the forward direction.
- daunorubicin + H+ + NADPH = 13-dihydrodaunorubicin + NADP+This reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | carbonyl reductase (NADPH) activity | |
Molecular Function | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | |
Biological Process | epithelial cell differentiation | |
Biological Process | glucocorticoid metabolic process | |
Biological Process | positive regulation of reactive oxygen species metabolic process | |
Biological Process | vitamin K metabolic process | |
Biological Process | xenobiotic metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCarbonyl reductase (NADPH)
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pan
Accessions
- Primary accessionH2QKZ8
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Expression
Gene expression databases
Interaction
Structure
Sequence
- Sequence statusComplete
- Length277
- Mass (Da)30,375
- Last updated2012-03-21 v1
- Checksum51A5A495EB4F4EC3
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2I3SK79 | A0A2I3SK79_PANTR | CBR1 | 172 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AACZ04064307 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
GABC01005225 EMBL· GenBank· DDBJ | JAA06113.1 EMBL· GenBank· DDBJ | mRNA | ||
GABF01003842 EMBL· GenBank· DDBJ | JAA18303.1 EMBL· GenBank· DDBJ | mRNA | ||
GABD01003512 EMBL· GenBank· DDBJ | JAA29588.1 EMBL· GenBank· DDBJ | mRNA | ||
GABE01000562 EMBL· GenBank· DDBJ | JAA44177.1 EMBL· GenBank· DDBJ | mRNA |