H2QKZ8 · H2QKZ8_PANTR

Function

Catalytic activity

  • H+ + NADPH + S-nitrosoglutathione = NADP+ + S-(hydroxysulfenamide)glutathione
  • H+ + menadione + NADPH = menadiol + NADP+
  • NADP+ + prostaglandin D2 = 15-oxoprostaglandin D2 + H+ + NADPH
    This reaction proceeds in the forward direction.
    EC:1.1.1.196 (UniProtKB | ENZYME | Rhea)
  • NADP+ + prostaglandin E1 = 15-oxoprostaglandin E1 + H+ + NADPH
    This reaction proceeds in the forward direction.
    EC:1.1.1.197 (UniProtKB | ENZYME | Rhea)
  • NADP+ + prostaglandin E2 = 15-oxoprostaglandin E2 + H+ + NADPH
    This reaction proceeds in the forward direction.
  • NADP+ + prostaglandin F2alpha = 15-oxoprostaglandin F2alpha + H+ + NADPH
    This reaction proceeds in the forward direction.
  • NADP+ + prostaglandin F2alpha = H+ + NADPH + prostaglandin E2
    This reaction proceeds in the backward direction.
    EC:1.1.1.189 (UniProtKB | ENZYME | Rhea)
  • a primary alcohol + NADP+ = an aldehyde + H+ + NADPH
    EC:1.1.1.71 (UniProtKB | ENZYME | Rhea)
  • a secondary alcohol + NADP+ = a ketone + H+ + NADPH
    EC:1.1.1.184 (UniProtKB | ENZYME | Rhea)
  • corticosterone + H+ + NADPH = 20beta-dihydrocorticosterone + NADP+
    This reaction proceeds in the forward direction.
  • cortisol + H+ + NADPH = 20beta-dihydrocortisol + NADP+
    This reaction proceeds in the forward direction.
  • daunorubicin + H+ + NADPH = 13-dihydrodaunorubicin + NADP+
    This reaction proceeds in the forward direction.

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functioncarbonyl reductase (NADPH) activity
Molecular Functionoxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
Biological Processepithelial cell differentiation
Biological Processglucocorticoid metabolic process
Biological Processpositive regulation of reactive oxygen species metabolic process
Biological Processvitamin K metabolic process
Biological Processxenobiotic metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Carbonyl reductase (NADPH)
  • EC number

Gene names

    • Name
      CBR1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pan

Accessions

  • Primary accession
    H2QKZ8
  • Secondary accessions
    • A0A2J8M7M3

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    277
  • Mass (Da)
    30,375
  • Last updated
    2012-03-21 v1
  • Checksum
    51A5A495EB4F4EC3
MSSGIHVALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFHQLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRDVCTELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTKKGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTDMAGPKATKSPEEGAETPVYLALLPPDAEGPHGQFVSEKRVEQW

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A2I3SK79A0A2I3SK79_PANTRCBR1172

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AACZ04064307
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
GABC01005225
EMBL· GenBank· DDBJ
JAA06113.1
EMBL· GenBank· DDBJ
mRNA
GABF01003842
EMBL· GenBank· DDBJ
JAA18303.1
EMBL· GenBank· DDBJ
mRNA
GABD01003512
EMBL· GenBank· DDBJ
JAA29588.1
EMBL· GenBank· DDBJ
mRNA
GABE01000562
EMBL· GenBank· DDBJ
JAA44177.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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