H2PHI3 · H2PHI3_PONAB

Function

function

Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

  • Selective cleavage of Arg-|-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa.
    EC:3.4.21.38 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

161550100150200250300350400450500550600
TypeIDPosition(s)Description
Active site412Charge relay system
Active site461Charge relay system
Active site563Charge relay system

GO annotations

AspectTerm
Cellular Componentextracellular space
Cellular Componentrough endoplasmic reticulum
Molecular Functioncalcium ion binding
Molecular Functionserine-type endopeptidase activity
Biological Processblood coagulation
Biological ProcessFactor XII activation
Biological Processpositive regulation of blood coagulation
Biological Processpositive regulation of fibrinolysis
Biological Processpositive regulation of plasminogen activation
Biological Processprotein autoprocessing
Biological Processresponse to misfolded protein
Biological Processzymogen activation

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Coagulation factor XII
  • EC number
  • Alternative names
    • Hageman factor

Gene names

    • Name
      F12
    • ORF names
      CR201_G0051613

Organism names

Accessions

  • Primary accession
    H2PHI3
  • Secondary accessions
    • A0A2J8RDT4
    • A0A6D2Y681

Proteomes

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

Type
IDPosition(s)Description
Signal1-19
ChainPRO_501457509920-615Coagulation factor XII
Disulfide bond47↔73
Disulfide bond61↔88
Disulfide bond121↔130
Disulfide bond200↔209
Disulfide bond238↔277

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain42-90Fibronectin type-II
Domain94-131EGF-like
Domain133-173Fibronectin type-I
Domain174-210EGF-like
Domain216-295Kringle
Region300-359Disordered
Compositional bias302-332Pro residues
Domain373-614Peptidase S1

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    615
  • Mass (Da)
    67,561
  • Last updated
    2012-03-21 v1
  • Checksum
    BAC77CAE338E72C2
MRALLLLGFLLVSLESTVSIPPWKAPKEHKHKAEEHTVVLTVTGEPCHFPFQYHRQLYHKCTHKGRPGPQPWCATTPNFDQDQRWGYCLEPKKVKDHCSKHSPCQKGGTCVNTPSGPHCLCPQHLTGNHCQKEKCFEPQLLRFFHENEIWYRSEQAAVARCQCKGPDAHCQRLASQACRTNPCLHGGRCLEVEGHPLCHCPVGYTGPFCDVDTKASCYDGRGLSYRGLARTTLSGAPCQPWASEATYRNVTAEQARHWGLGGHAFCRNPDNDIRPWCFVLNGDRLSWEYCDLAQCQTPTQAAPPTPVSPRLHVLLTPPQPAAPKPQPTTRTPPQSQTPGALPAKREQPPSLTRNGPLSCGQRLRKSLSSMTRVVGGLVALRGAHPYIAALYWGHSFCAGSLIAPCWVLTAAHCLQDRPAPEDLTVVLGQERHNHSCEQCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGSCALLSPYVQPVCLPSGAARPSETALCQVAGWGHQFEGAEEYASFLQEAQVPFLPLERCSAPDVHGASILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKPGVYTDVAYYLAWIREHTVS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias302-332Pro residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NDHI03003708
EMBL· GenBank· DDBJ
PNJ06672.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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