H2PHI3 · H2PHI3_PONAB
- ProteinCoagulation factor XII
- GeneF12
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids615 (go to sequence)
- Protein existencePredicted
- Annotation score4/5
Function
function
Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa.
Catalytic activity
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 412 | Charge relay system | |||
Active site | 461 | Charge relay system | |||
Active site | 563 | Charge relay system | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular space | |
Cellular Component | rough endoplasmic reticulum | |
Molecular Function | calcium ion binding | |
Molecular Function | serine-type endopeptidase activity | |
Biological Process | blood coagulation | |
Biological Process | Factor XII activation | |
Biological Process | positive regulation of blood coagulation | |
Biological Process | positive regulation of fibrinolysis | |
Biological Process | positive regulation of plasminogen activation | |
Biological Process | protein autoprocessing | |
Biological Process | response to misfolded protein | |
Biological Process | zymogen activation |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameCoagulation factor XII
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pongo
Accessions
- Primary accessionH2PHI3
- Secondary accessions
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-19 | ||||
Chain | PRO_5014575099 | 20-615 | Coagulation factor XII | ||
Disulfide bond | 47↔73 | ||||
Disulfide bond | 61↔88 | ||||
Disulfide bond | 121↔130 | ||||
Disulfide bond | 200↔209 | ||||
Disulfide bond | 238↔277 | ||||
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 42-90 | Fibronectin type-II | |||
Domain | 94-131 | EGF-like | |||
Domain | 133-173 | Fibronectin type-I | |||
Domain | 174-210 | EGF-like | |||
Domain | 216-295 | Kringle | |||
Region | 300-359 | Disordered | |||
Compositional bias | 302-332 | Pro residues | |||
Domain | 373-614 | Peptidase S1 | |||
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length615
- Mass (Da)67,561
- Last updated2012-03-21 v1
- ChecksumBAC77CAE338E72C2
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 302-332 | Pro residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
NDHI03003708 EMBL· GenBank· DDBJ | PNJ06672.1 EMBL· GenBank· DDBJ | Genomic DNA |