H2MCM1 · CAHM1_ORYLA
- ProteinCalcium homeostasis modulator 1
- GeneCALHM1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids351 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Pore-forming subunit of a voltage-gated ion channel. Has poor ion selectivity and forms a wide pore that mediates permeation of small ions including Ca2+, Na+, K+ and Cl-, as well as larger ions such as ATP4-.
Catalytic activity
- ATP(in) = ATP(out)
- Ca2+(in) = Ca2+(out)
- Mg2+(in) = Mg2+(out)
- Na+(in) = Na+(out)
- K+(in) = K+(out)
- Li+(in) = Li+(out)
- Rb+(in) = Rb+(out)
- Cs+(in) = Cs+(out)
- chloride(in) = chloride(out)
Activity regulation
Activated in response to membrane depolarization and low extracellular Ca2+ concentration. Inhibited by ruthenium red.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | basolateral plasma membrane | |
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | plasma membrane | |
Molecular Function | calcium channel activity | |
Molecular Function | monoatomic cation channel activity | |
Biological Process | ATP export |
Keywords
- Molecular function
- Biological process
- Ligand
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameCalcium homeostasis modulator 1
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Atherinomorphae > Beloniformes > Adrianichthyidae > Oryziinae > Oryzias
Accessions
- Primary accessionH2MCM1
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Basolateral cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Topological domain | 1-20 | Cytoplasmic | |||
Transmembrane | 21-36 | Helical; Name=S1 | |||
Topological domain | 37-48 | Extracellular | |||
Transmembrane | 49-71 | Helical; Name=S2 | |||
Topological domain | 72-98 | Cytoplasmic | |||
Transmembrane | 99-124 | Helical; Name=S3 | |||
Topological domain | 125-177 | Extracellular | |||
Transmembrane | 178-203 | Helical; Name=S4 | |||
Topological domain | 204-351 | Cytoplasmic | |||
Keywords
- Cellular component
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Mutagenesis | 1-11 | Markedly enhances ATP release. | |||
Mutagenesis | 1-19 | Markedly enhances ATP release. | |||
PTM/Processing
Features
Showing features for chain, disulfide bond, lipidation, glycosylation.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000460370 | 1-351 | Calcium homeostasis modulator 1 | ||
Disulfide bond | 41↔126 | ||||
Disulfide bond | 43↔160 | ||||
Lipidation | 100 | S-palmitoyl cysteine | |||
Glycosylation | 139 | N-linked (GlcNAc...) asparagine | |||
Lipidation | 205 | S-palmitoyl cysteine | |||
Post-translational modification
N-glycosylated.
Palmitoylated.
Keywords
- PTM
Expression
Gene expression databases
Interaction
Subunit
Oligomerizes to form hexamers and octamers. Does not form gap junctions (By similarity).
Associates with CALHM3 as a pore-forming subunit in a hetero-hexameric channel complex (By similarity).
Associates with CALHM3 as a pore-forming subunit in a hetero-hexameric channel complex (By similarity).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 9-36 | Central pore | |||
Region | 62-69 | Phospholipid-binding | |||
Region | 104-116 | Phospholipid-binding | |||
Region | 189-199 | Phospholipid-binding | |||
Region | 259-281 | Disordered | |||
Domain
A phospholipid-binding pocket is formed between conserved regions of S3 and S4 helices of one subunit and S2 of the adjacent subunit. It may regulate channel assembly and gating.
Sequence similarities
Belongs to the CALHM family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length351
- Mass (Da)40,485
- Last updated2018-12-05 v2
- MD5 ChecksumA4577FB747CAF06F68101249BAA456B9
Keywords
- Technical term