H2MCM1 · CAHM1_ORYLA

Function

function

Pore-forming subunit of a voltage-gated ion channel. Has poor ion selectivity and forms a wide pore that mediates permeation of small ions including Ca2+, Na+, K+ and Cl-, as well as larger ions such as ATP4-.

Catalytic activity

Activity regulation

Activated in response to membrane depolarization and low extracellular Ca2+ concentration. Inhibited by ruthenium red.

GO annotations

AspectTerm
Cellular Componentbasolateral plasma membrane
Cellular Componentendoplasmic reticulum membrane
Cellular Componentplasma membrane
Molecular Functioncalcium channel activity
Molecular Functionmonoatomic cation channel activity
Biological ProcessATP export

Keywords

Protein family/group databases

    • 1.A.84.1.9the calcium homeostasis modulator ca2+ channel (calhm-c) family

Names & Taxonomy

Protein names

  • Recommended name
    Calcium homeostasis modulator 1

Gene names

    • Name
      CALHM1

Organism names

  • Taxonomic identifier
  • Strain
    • Hd-rR
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Atherinomorphae > Beloniformes > Adrianichthyidae > Oryziinae > Oryzias

Accessions

  • Primary accession
    H2MCM1

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Endoplasmic reticulum membrane
; Multi-pass membrane protein
Basolateral cell membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

Type
IDPosition(s)Description
Topological domain1-20Cytoplasmic
Transmembrane21-36Helical; Name=S1
Topological domain37-48Extracellular
Transmembrane49-71Helical; Name=S2
Topological domain72-98Cytoplasmic
Transmembrane99-124Helical; Name=S3
Topological domain125-177Extracellular
Transmembrane178-203Helical; Name=S4
Topological domain204-351Cytoplasmic

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis1-11Markedly enhances ATP release.
Mutagenesis1-19Markedly enhances ATP release.

PTM/Processing

Features

Showing features for chain, disulfide bond, lipidation, glycosylation.

Type
IDPosition(s)Description
ChainPRO_00004603701-351Calcium homeostasis modulator 1
Disulfide bond41↔126
Disulfide bond43↔160
Lipidation100S-palmitoyl cysteine
Glycosylation139N-linked (GlcNAc...) asparagine
Lipidation205S-palmitoyl cysteine

Post-translational modification

N-glycosylated.
Palmitoylated.

Keywords

Expression

Gene expression databases

Interaction

Subunit

Oligomerizes to form hexamers and octamers. Does not form gap junctions (By similarity).
Associates with CALHM3 as a pore-forming subunit in a hetero-hexameric channel complex (By similarity).

Protein-protein interaction databases

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region9-36Central pore
Region62-69Phospholipid-binding
Region104-116Phospholipid-binding
Region189-199Phospholipid-binding
Region259-281Disordered

Domain

A phospholipid-binding pocket is formed between conserved regions of S3 and S4 helices of one subunit and S2 of the adjacent subunit. It may regulate channel assembly and gating.

Sequence similarities

Belongs to the CALHM family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    351
  • Mass (Da)
    40,485
  • Last updated
    2018-12-05 v2
  • MD5 Checksum
    A4577FB747CAF06F68101249BAA456B9
MDKFRMMFQFLQSNQESFMNGICGIMALASAQMYSSFEFSCPCMPEYNYTYGIGLLIIPPIWFFLLGFVLNNNVSVLAEEWKRPTGRRTKDPSVLRYMLCSITQRSLIAPAVWVSVTLMDGKSFLCAFSINLDIEKFGNASLVIGMTETEKLKFLARIPCKDLFEDNEVRVAATRYIKCISQACGWMFLLMMTFTAFLIRAIRPCFTQAAFLKTKYWSHYIDIERKMFDETCKEHAKSFAKVCIHQYFENISGEMQNFHRHQSKDTSDAEEEEKQRSDEDKLLGIKAQEDMNKVLWNWHTCKPALALRKDHLDTESNGKLNGTMNGAVNGFAQGHTHDVAKKEWAVYYSKV

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help