H2LW33 · H2LW33_ORYLA

Function

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

  • Endopeptidase of broad specificity.
    EC:3.4.24.81 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Features

Showing features for binding site, active site.

1747100200300400500600700
Type
IDPosition(s)Description
Binding site386Zn2+ (UniProtKB | ChEBI); catalytic
Active site387
Binding site390Zn2+ (UniProtKB | ChEBI); catalytic
Binding site396Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentplasma membrane
Cellular Componentsynaptic membrane
Molecular Functionmetal ion binding
Molecular Functionmetalloendopeptidase activity involved in amyloid precursor protein catabolic process
Molecular FunctionSH3 domain binding
Biological Processmembrane protein ectodomain proteolysis
Biological ProcessNotch signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Disintegrin and metalloproteinase domain-containing protein 10
  • EC number
  • Alternative names
    • Kuzbanian protein homolog

Gene names

    • Name
      adam10a

Organism names

  • Taxonomic identifier
  • Strain
    • Hd-rR
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Atherinomorphae > Beloniformes > Adrianichthyidae > Oryziinae > Oryzias

Accessions

  • Primary accession
    H2LW33

Proteomes

Subcellular Location

Membrane
; Single-pass type I membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane680-707Helical

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-17
ChainPRO_501733854918-747Disintegrin and metalloproteinase domain-containing protein 10

Keywords

PTM databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain223-459Peptidase M12B
Domain460-554Disintegrin
Region717-747Disordered
Compositional bias724-747Polar residues

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    747
  • Mass (Da)
    83,859
  • Last updated
    2018-12-05 v2
  • MD5 Checksum
    4291E7670C330AE5EDFA5F01AD9E5A6A
MIVALVVAFCCLHHTTGQLRTPLNKYISHYEELSYDTEALHQSHQRAKRALSPHDMTVHLNFHAHGRHFPLRMKRDTTLFTPDLVIEDSGDQPPLDTSHIYSGEIFGERNTRIHGSVVDGRFEGFINTDLGTYYVEPAERYLQNKNTTVHSVIYHEDDIDYPHKYGPEGGCAHDSVFERMKKHQMSAVEESDKEMNFEKEDEEEDTYGPVILRKKRAAENEKTVCQLFIQTDHLFLKYYGSREAVLAQISNHVSAINAIYMNTDFMGIKGISFMVKRIRINGTKEANDESNPFRFSNIGVETFLNLNSEQNHDDFCLAYVFTDRDFDDGVLGLAWVGSTAGSSGGICQKTKKYGDGKYQSLNTGIITVQNYGSHIPPTVSHITFAHEVGHNFGSHHDSEMECKPGESNDRNTKKLGNYIMYARATSGSKLNNNKFSQCSLHSINSVLSRKRNICFVEPGQASCGNGLVENGEECDCGYSEECKDPCCYSASEEISKRCKIKPGTECSPSGGPCCSNECKFKNSSNTCRLESDCALKGFCNGSSALCPKSKAKEDFTTCNSETQICQNGVCTGSICHKYKLEDCICSSEDIMNMPAELCHVCCQESLDPTTCSSTSSERWAKYFNKTVLTMPPGSPCNDFKGYCDVLKRCRVVDADGPLLRLRKSIFNPELYENISDWLGAYWWAILLIGIGYIVLMMGFICLCSPFIKSHNKSYNDKKPLPVTRRTPQHSSSSVRYTAANPRNTRRT

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
H2LW31H2LW31_ORYLAadam10a692

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias724-747Polar residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

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