H2INY7 · H2INY7_RAHAC

Function

function

Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.

Catalytic activity

Cofactor

FMNH2 (UniProtKB | Rhea| CHEBI:57618 )

Note: Reduced FMN (FMNH2).

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site48NADP+ (UniProtKB | ChEBI)
Binding site54NADP+ (UniProtKB | ChEBI)
Binding site125-127FMN (UniProtKB | ChEBI)
Binding site238-239FMN (UniProtKB | ChEBI)
Binding site278FMN (UniProtKB | ChEBI)
Binding site293-297FMN (UniProtKB | ChEBI)
Binding site319FMN (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionchorismate synthase activity
Biological Processamino acid biosynthetic process
Biological Processaromatic amino acid family biosynthetic process
Biological Processchorismate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Chorismate synthase
  • EC number
  • Short names
    CS
  • Alternative names
    • 5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

    • Name
      aroC
    • Ordered locus names
      Rahaq2_1285

Organism names

Accessions

  • Primary accession
    H2INY7

Proteomes

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the chorismate synthase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    361
  • Mass (Da)
    39,074
  • Last updated
    2012-03-21 v1
  • Checksum
    7A3BDCCF4CAF1F52
MAGNSIGQFFRVTTFGESHGVALGCIIDGVPPGISLTEADLQHDLDRRRPGTSRYTTQRREADEVKILSGVFEGVTTGTSIGLIIQNTDQRSQDYSAIKDVFRPGHADYTYEQKYGVRDYRGGGRSSARETAMRVAAGAVAKKYLLEKFGVKVRGYMSQMGDITCELKDWDLVETNPFFCPDAGKLEALDELMRALKKEGDSIGAKITVVADHVPVGLGEPVFDRLDADLAHALMSINAVKGVEIGDGFAVVAKRGSENRDEITPDGFQSNHAGGILGGISSGQPVIAHLALKPTSSITVPGRTINREGEQVEMITKGRHDPCVGIRAVPIAEAMMAIVLMDHLLRQRAQNGDVHSTVPRW

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP003244
EMBL· GenBank· DDBJ
AEX51166.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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