H2DQW4 · H2DQW4_9FLAV

Function

function

Acts as a cofactor for the NS3 protease activity.
Packages viral RNA to form a viral nucleocapsid and thereby protects viral RNA. Also plays a role in transcription regulation. Protects the incoming virus against IFN-induced effectors.
Plays a role in the regulation of viral RNA replication.

Catalytic activity

Features

Showing features for active site, site.

TypeIDPosition(s)Description
Active site49For N-terminal protease activity
Active site69For N-terminal protease activity
Site168-169Cleavage; by autolysis
Active site1658Charge relay system; for serine protease NS3 activity
Active site1695Charge relay system; for serine protease NS3 activity
Active site1752Charge relay system; for serine protease NS3 activity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componenthost cell cytoplasm
Cellular Componenthost cell membrane
Cellular Componentmembrane
Cellular Componentvirion membrane
Molecular FunctionATP binding
Molecular Functionchannel activity
Molecular Functioncysteine-type endopeptidase activity
Molecular FunctionGTP binding
Molecular Functionribonuclease T2 activity
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionRNA binding
Molecular FunctionRNA helicase activity
Molecular FunctionRNA-dependent RNA polymerase activity
Molecular Functionserine-type endopeptidase activity
Molecular Functionserine-type exopeptidase activity
Biological Processfusion of virus membrane with host endosome membrane
Biological Processinduction by virus of host autophagy
Biological Processmonoatomic ion transmembrane transport
Biological Processproteolysis
Biological Processsymbiont entry into host cell
Biological Processsymbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
Biological Processviral protein processing
Biological Processviral RNA genome replication
Biological Processvirion attachment to host cell
Biological Processvirus-mediated perturbation of host defense response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Genome polyprotein

Organism names

  • Taxonomic identifier
  • Strain
    • 3156
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Kitrinoviricota > Flasuviricetes > Amarillovirales > Flaviviridae > Pestivirus > Pestivirus bovis

Accessions

  • Primary accession
    H2DQW4

Proteomes

Subcellular Location

Host cytoplasm
Membrane
; Peripheral membrane protein
Virion membrane
; Peripheral membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane1036-1059Helical
Transmembrane1107-1131Helical
Transmembrane1143-1163Helical
Transmembrane1193-1210Helical
Transmembrane1217-1238Helical
Transmembrane1250-1271Helical
Transmembrane1283-1304Helical

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain1-168Peptidase C53
Region49-72Disordered
Region174-209Disordered
Compositional bias176-208Basic and acidic residues
Region224-245Disordered
Domain1441-1589Peptidase C74
Domain1590-1763Peptidase S31
Domain1802-1960Helicase ATP-binding
Domain1978-2143Helicase C-terminal
Domain3518-3641RdRp catalytic

Sequence similarities

Belongs to the pestivirus polyprotein family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    3,898
  • Mass (Da)
    438,155
  • Last updated
    2012-03-21 v1
  • Checksum
    EF8A19D73F9BC33B
MELITNELLYKTYKQKPAGVEEPVYNRAGDPLFGERGEVHPQATLKLPHKRGEREVPTNLASLPKRGDCRSGNSKGPVSGIYLKPGPLFYQDYKGPVYHRAPLEYFQEASMCETTKRIGRVTGSDGKLYHIYVCIDGCIIVKSATKYRQKVLKWVYNKLNCPLWVSSCSDTNAEGATRKKQQKPDRLEKGRMKITPKESEKDSKTKPPDATIVVDGVKYLVKKKGKVKSKNTQDGLYHNKNKPQEPRKKLEKALLAWAIIGLVLFQVAVGENITQWNLQDNGTEGIQRAMFQRGINRSLHGIWPEKICTGVPSHLVTDTELKAIHGMMDASEKTNYTCCRHQRHEWNKHGWRNWFNIEPWILLMNKTQANLTEGQPPRECAVTCRYDRDSDLNVVTQARDSPTPLTGCKKGKNFSFAGVLVQGPCNFEIAVSDVLFKEHDCTSVIQDTAHYLVDGMTNSLESARQGTAKLTTWFGRQLGILGKKLENKSKTWFGAYAASPYCEVERRLGYIWYTKNCTPACLPKNTKIIGPGKFDTNAEDGKILHEMGGHLSEVLLLSVVVLSNFAPETASVIYLILHFTIPQGHTDIHDCDKNQLNLTVELTTAEVIPGSVWNLGKYVCIRPDWWPYETATVLVLEEVGQVIKIVLRALRDLMRIWNAATTTAFLVCLVKVARGQVLQGILWLILITGAQGLPACKPDFSYAIAKNNEIGPLGATGLTTQWYEYSDGMRLQDTEVVVWCKDGEIKYLITCEREARYLAILHTRALPTSVVFEKIIKGKEQEDVVEMDDDFEFGLCPCDAKPLVRGKFNTTLLNGPAFQMVCPIGWTGTVSCALANKDTLALTVVRTYTRHKPFPYRQGCITQKTLGEDLYDCVLGGNWTCVPGDQSRYTGGFIESCKWCGYKFQKSEGLPHYPIGKCRLNNETGYRLVDDTSCNREGVAIVPHGQVKCKIGDTTVQVIAMDTKLGPMPCKPHEIISSEGPIEKTACTFNYTRTLKNKYFEPRDSYFQQYMLKGDYQYWFDLEVTDRHRDYFAESILVVVVALLGGRYVLWLLVTYMVLSEQKASGAQYGAGEVVMMGNLLTHDNVEVVTYFFLLYLLLREESVKKWVLLLYHILVAHPLKSVIVILLMIGDVVKADPGGQDYLGQIDVCFTMVVLIIIGLIIARRDPTIVPLITIVASLRVTGLTYSPGVDAAMAVITITLLMASYVTDYFRYKRWLQCILSLVSGVFLIRSLIHLGRIETPEVTIPSWRPLTLILLYLISTTVVTMWKIDLAGLLLQGVPILLLITTLWADFLTLILILPTYELVKLYYLKTIKTDIEKSWLGGLDYKRVDSIYDVDESGEGVYLFPSRQKAQKNFSMLLPLVRATLISCISSKWQLIYMAYLSVDFMYYMHRKVIEEISGGTNVISRVIAALIELNWSMEEEESKGLKKFFILSGRLRALIMKHKVRNQTVASWYGEEEVYGMPKIITIIRACTLNKNKHCIICTVCEAKEWKGGNCPKCGRYGKPITCGMTLADFEERYYKRIFIREGTFEGPFRQEYSGFVQYAARGQLFLRNLPILATKVKMLMIGNLGEEVGDLEHLGWILRGPAVCKKITEHERCHVNILDKLTAFFGVMPRGTTPRAPVRFPTALLKVRRGLETGWAYTHQGGISSVDHVTAGKDLLVCDSMGRTRVVCQSNNKLTDETEYGVKTDSGCPDGARCYVLNPEAVNISGSKGAIVHLQKTGGEFTCVTASGTPAFFDLKNLKGWSGLPIFEASSGRVVGRVKVGKNEESKPTKLMSGIQTVSKSTADLTEMVKKITSMNRGDFRQITLATGAGKTTELPKAVIEEIGRHKRVLVLIPLRAAAESVYQYMRSKHPSISFNLRIGDMKEGDMATGITYASYGYFCQLPQPKLRAAMVEYSYIFLDEYHCATPEQLAVIGKIHRFSESIRVVAMTATPAGSVTTTGQKHPIEEFIAPEVMKGEDLGSQFIDIAGLKIPVEEMKGNMLVFVPTRNMAVDVAKKLKAKGYNSGYYYSGEDPANLRVVTSQSPYVVVATNAIESGVTLPDLDTVVDTGLKCEKRVRVSSKIPFIVTGLKRMAVTVGEQAQRRGRVGRVKPGRYYRSQETATGSKDYHYDLLQAQRYGIEDGINVTKSFREMNYDWSLYEEDSLLITQLEILNNLLISEDLPAAVKNIMARTDHPEPIQLAYNSYEVQVPVLFPKIRNGEVTDTYENYSFLNARKLGEDVPVYIYATEDEDLAVDLLGLDWPDPGNQQVVETGKALKQVVGLSTAENALLIALFGYVGYQALSKRHVPMITDIYTIEDQRLEDTTHLQYAPNAIRTEGKEAELKELAVGDLDKIMESISDYASGGLEFVRSQAEKIRSAPAFEENMEAAKGYAQKLIDALIENKETIIRYGLWGTHTALYKSIAARLGHETAFATLVIKWLAFGGESVSDHVRQAALDLVVYYVMNKPSFPGDSETQQEGRRFIASLFISALATYTYKTWNYHNLAKVVEPALAYLPYATSALKMFTPTRLESVVILSTTIYKTYLSIRKGKSDGLLGTGISAAMEILSQNPVSVGISVMLGVGAIAAHNAIESSEQKRTLLMKVFVKNFLDQAATDELVKENPEKIIMALFEAVQTIGNPLRLIYHLYGVYYKGWEAKELSERTAGRNLFTLIMFEAFELLGMDSEGKIRNLSGNYILDLIYSLHKHINRGLKKVILGWAPAPFSCDWTPSDERIRLPTDNYLRVETKCPCGYEMKALRNVGGSLTKVEEKGPFLCRNRPGRGPVNYRVTKYYDNNLKEIKPVAKLEGLVEHYYKGVTARIDYSEGKTLLATDKWEVEHGTITRLAKRYTGVGFRGAYLGDEPNHRDLVERDCATITKSTVQFLKMKKGCAFTYDLTISNLTRLIELVHRNNLEEKEIPTATVTTWLAYTFVNEDVGTIKPVLGERVIPDPVVDVNLQPEVQVDTSEVGITIIGKEAVMTTGVTPVMEKVKPDADNNQSTVKIGLDEGNYPGPGVQTHTLVEEIHNRDARPYIMVLGSKSSMSNRAKTARNINLYTGNDPREIRDLMAEGRMLVVALRDIDPDLSELVDFKGTFLDREALEALSLGQPKPKQVTKAAIRDLLKEERQVEIPDWFTSDDPVFLDVAMKKDKYHLVGDVGEVKEQAKALGATDQTRIVKEVGSRTYTMKLSSWFLQASNKQMSLTPLFEELLLRCPPATKSNKGHMASAYQLAQGNWEPLGCGVHLGTVPARRVKIHPYEAYLKLKDLVEEEEKKPRIRDTVIREHNKWILKKIKFQGNLNTKKMLNPGKLSEQLDREGHKRNIYNNQISTVMSSAGIRLEKLPIVRAQTDTKSFHEAIRDKIDKNENRQNPELHNKLLEIFHTIADPSLKHTYGEVTWEQLEAGINRKGAAGFLEKKNIGEVLDSEKHLVEQLVRDLKAGRKIRYYETAIPKNEKRDVSDDWQAGDLVDEKKPRVIQYPEAKTRLAITKVMYNWVKQQPVVIPGYEGKTPLFNIFNKVRKEWDLFNEPVAVSFDTKAWDTQVTSRDLHLIGEIQKYYYRKEWHKFIDTITDHMVEVPVITADGEVYIRNGQRGSGQPDTSAGNSMLNVLTMIYAFCESTGVPYKSFNRVARIHVCGDDGFLITEKGLGLKFSNKGMQILHEAGKPQKLTEGEKMKVAYRFEDIEFCSHTPVPVRWSDNTSSYMAGRDTAVILSKMATRLDSSGERGTTAYEKAVAFSFLLMYSWNPLVRRICLLVLSQRPETAPSTQTTYYYKGDPIGAYKDVIGRNLSELKRTGFEKLANLNLSLSTLGIWTKHTSKRIIQDCVAIGKEEGNWLVNADRLISSKTGHLYIPDKGFTLQGKHYEQLQLGAETNPVMGVGTERYRLGPIVNLLLRRLRVLLMAAVSTSS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias176-208Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JN644055
EMBL· GenBank· DDBJ
AEY79714.1
EMBL· GenBank· DDBJ
Genomic RNA
JN704144
EMBL· GenBank· DDBJ
AFA41945.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

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