H2DH10 · H2DH10_9GEMI
- ProteinTranscriptional activator protein
- GeneC2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids134 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Strong activator of the late viral genes promoters. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. Also suppresses the host basal defense by interacting with and inhibiting SNF1 kinase, a key regulator of cell metabolism implicated in innate antiviral defense. Determines pathogenicity.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | host cell cytoplasm | |
Cellular Component | host cell nucleus | |
Cellular Component | viral capsid | |
Molecular Function | DNA binding | |
Molecular Function | metal ion binding | |
Molecular Function | structural molecule activity |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameTranscriptional activator protein
- Short namesTrAP
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageViruses > Monodnaviria > Shotokuvirae > Cressdnaviricota > Repensiviricetes > Geplafuvirales > Geminiviridae > Begomovirus
Accessions
- Primary accessionH2DH10
Subcellular Location
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Monomer. Homodimer. Homooligomer. Self-interaction correlates with nuclear localization and efficient activation of transcription.
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1-15 | Polar residues | |||
Region | 1-26 | Disordered | |||
Region | 73-115 | Disordered | |||
Compositional bias | 86-100 | Basic and acidic residues | |||
Compositional bias | 101-115 | Polar residues | |||
Domain
The zinc finger and the transactivation region are involved in PTGS suppression.
Sequence similarities
Belongs to the geminiviridae transcriptional activator protein family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length134
- Mass (Da)15,194
- Last updated2012-03-21 v1
- Checksum4BC60A128EC7629F
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1-15 | Polar residues | |||
Compositional bias | 86-100 | Basic and acidic residues | |||
Compositional bias | 101-115 | Polar residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JN604490 EMBL· GenBank· DDBJ | AEY77425.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN604493 EMBL· GenBank· DDBJ | AEY77442.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN604496 EMBL· GenBank· DDBJ | AEY77460.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN604497 EMBL· GenBank· DDBJ | AEY77466.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN604498 EMBL· GenBank· DDBJ | AEY77472.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN604499 EMBL· GenBank· DDBJ | AEY77478.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN604500 EMBL· GenBank· DDBJ | AEY77484.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HE806437 EMBL· GenBank· DDBJ | CCH63304.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HF968755 EMBL· GenBank· DDBJ | CCX28580.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HG969197 EMBL· GenBank· DDBJ | CDO49999.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HG969200 EMBL· GenBank· DDBJ | CDO50017.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HG969257 EMBL· GenBank· DDBJ | CDO50173.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HG969263 EMBL· GenBank· DDBJ | CDO50209.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LN680624 EMBL· GenBank· DDBJ | CEJ95659.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LN680625 EMBL· GenBank· DDBJ | CEJ95665.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LN680626 EMBL· GenBank· DDBJ | CEJ95671.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH475359 EMBL· GenBank· DDBJ | QAB47420.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK468694 EMBL· GenBank· DDBJ | QGJ83131.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK468695 EMBL· GenBank· DDBJ | QGJ83137.1 EMBL· GenBank· DDBJ | Genomic DNA |