H2DH10 · H2DH10_9GEMI

  • Protein
    Transcriptional activator protein
  • Gene
    C2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Strong activator of the late viral genes promoters. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. Also suppresses the host basal defense by interacting with and inhibiting SNF1 kinase, a key regulator of cell metabolism implicated in innate antiviral defense. Determines pathogenicity.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componenthost cell cytoplasm
Cellular Componenthost cell nucleus
Cellular Componentviral capsid
Molecular FunctionDNA binding
Molecular Functionmetal ion binding
Molecular Functionstructural molecule activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Transcriptional activator protein
  • Short names
    TrAP

Gene names

    • Name
      C2
    • Synonyms
      AC2
      , TrAP
      , TrAp

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • KW1
    • Th4
    • Sal2
    • Taq2
    • Th1
  • Taxonomic lineage
    Viruses > Monodnaviria > Shotokuvirae > Cressdnaviricota > Repensiviricetes > Geplafuvirales > Geminiviridae > Begomovirus

Accessions

  • Primary accession
    H2DH10

Subcellular Location

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Monomer. Homodimer. Homooligomer. Self-interaction correlates with nuclear localization and efficient activation of transcription.

Family & Domains

Features

Showing features for compositional bias, region.

Type
IDPosition(s)Description
Compositional bias1-15Polar residues
Region1-26Disordered
Region73-115Disordered
Compositional bias86-100Basic and acidic residues
Compositional bias101-115Polar residues

Domain

The zinc finger and the transactivation region are involved in PTGS suppression.

Sequence similarities

Belongs to the geminiviridae transcriptional activator protein family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    134
  • Mass (Da)
    15,194
  • Last updated
    2012-03-21 v1
  • Checksum
    4BC60A128EC7629F
MRPSSPSQAHSTQVPIKVQHRLAKKGTRRRRVDLDCGCSYFIALRCHGYGFTHRGTHHCSSSREWRVYLGDNKSPVFQDNRAPQQAIPEKPRHHHSADTVQSQPEESVGDAQMFSNLPNLDDLTASDWSFLKGI

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-15Polar residues
Compositional bias86-100Basic and acidic residues
Compositional bias101-115Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JN604490
EMBL· GenBank· DDBJ
AEY77425.1
EMBL· GenBank· DDBJ
Genomic DNA
JN604493
EMBL· GenBank· DDBJ
AEY77442.1
EMBL· GenBank· DDBJ
Genomic DNA
JN604496
EMBL· GenBank· DDBJ
AEY77460.1
EMBL· GenBank· DDBJ
Genomic DNA
JN604497
EMBL· GenBank· DDBJ
AEY77466.1
EMBL· GenBank· DDBJ
Genomic DNA
JN604498
EMBL· GenBank· DDBJ
AEY77472.1
EMBL· GenBank· DDBJ
Genomic DNA
JN604499
EMBL· GenBank· DDBJ
AEY77478.1
EMBL· GenBank· DDBJ
Genomic DNA
JN604500
EMBL· GenBank· DDBJ
AEY77484.1
EMBL· GenBank· DDBJ
Genomic DNA
HE806437
EMBL· GenBank· DDBJ
CCH63304.1
EMBL· GenBank· DDBJ
Genomic DNA
HF968755
EMBL· GenBank· DDBJ
CCX28580.1
EMBL· GenBank· DDBJ
Genomic DNA
HG969197
EMBL· GenBank· DDBJ
CDO49999.1
EMBL· GenBank· DDBJ
Genomic DNA
HG969200
EMBL· GenBank· DDBJ
CDO50017.1
EMBL· GenBank· DDBJ
Genomic DNA
HG969257
EMBL· GenBank· DDBJ
CDO50173.1
EMBL· GenBank· DDBJ
Genomic DNA
HG969263
EMBL· GenBank· DDBJ
CDO50209.1
EMBL· GenBank· DDBJ
Genomic DNA
LN680624
EMBL· GenBank· DDBJ
CEJ95659.1
EMBL· GenBank· DDBJ
Genomic DNA
LN680625
EMBL· GenBank· DDBJ
CEJ95665.1
EMBL· GenBank· DDBJ
Genomic DNA
LN680626
EMBL· GenBank· DDBJ
CEJ95671.1
EMBL· GenBank· DDBJ
Genomic DNA
MH475359
EMBL· GenBank· DDBJ
QAB47420.1
EMBL· GenBank· DDBJ
Genomic DNA
MK468694
EMBL· GenBank· DDBJ
QGJ83131.1
EMBL· GenBank· DDBJ
Genomic DNA
MK468695
EMBL· GenBank· DDBJ
QGJ83137.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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