H1W5H5 · H1W5H5_COLHI

Function

function

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
[2Fe-2S] cluster (UniProtKB | Rhea| CHEBI:190135 )

Note: Binds 1 [2Fe-2S] cluster.
[3Fe-4S] cluster (UniProtKB | Rhea| CHEBI:21137 )

Note: Binds 1 [3Fe-4S] cluster.
[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Function2 iron, 2 sulfur cluster binding
Molecular Function3 iron, 4 sulfur cluster binding
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionelectron transfer activity
Molecular Functionmetal ion binding
Molecular Functionsuccinate dehydrogenase (quinone) activity
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
  • EC number

Gene names

    • ORF names
      CH063_04259
      , CH63R_00525

Organism names

Accessions

  • Primary accession
    H1W5H5

Proteomes

Organism-specific databases

Subcellular Location

Mitochondrion inner membrane
; Peripheral membrane protein

Keywords

Interaction

Subunit

Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-39Disordered
Domain46-1392Fe-2S ferredoxin-type
Domain181-2114Fe-4S ferredoxin-type

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    277
  • Mass (Da)
    31,471
  • Last updated
    2012-03-21 v1
  • Checksum
    3E753822D0F319FF
MASLRSSSRVLGSATKATFRPAVTVPRRGLATPSDRVPRTKEPEMKKFTIYRWNPDTPTEKPRMQEYTLDLNKTGPMMLDALIRIKNELDPTLTFRRSCREGICGSCAMNINGQNTLACLCRIPKESSSDVKVYPLPHTYVVKDLVPDLTQFYKQYRSIKPYLQRDTPAPDGKEYRQSVADRKKLSGLYECILCACCSTSCPSYWWNSEEYLGPAILLQSYRWLADSRDEKTAERKAALDNSMSLYRCHTILNCTRACPKGLNPGKAIAEIKKQMAF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CACQ02010089
EMBL· GenBank· DDBJ
CCF47739.1
EMBL· GenBank· DDBJ
Genomic DNA
LTAN01000001
EMBL· GenBank· DDBJ
OBR15345.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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