H1VY66 · H1VY66_COLHI
- ProteinLysophospholipase NTE1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1524 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium.
Catalytic activity
- a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H+
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 1254 | Nucleophile | ||||
Sequence: S | ||||||
Active site | 1372 | Proton acceptor | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | lysophospholipase activity | |
Biological Process | phosphatidylcholine catabolic process | |
Biological Process | regulation of phospholipid biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLysophospholipase NTE1
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Glomerellales > Glomerellaceae > Colletotrichum > Colletotrichum destructivum species complex
Accessions
- Primary accessionH1VY66
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 51-71 | Helical | ||||
Sequence: LFGRLILAILSLVSSILYWAI | ||||||
Transmembrane | 92-114 | Helical | ||||
Sequence: VTMNATTLMVIVVAIISAVSWVV |
Keywords
- Cellular component
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 221-246 | Disordered | ||||
Sequence: DTDPCDSYGADSADAGEEEDMSSPHG | ||||||
Region | 279-381 | Disordered | ||||
Sequence: RSTDDETPESTASSAGLRTSPFPRNAGFRRMPSDPVSPFPATPEFPESTEERPGVRIEEPPRRAATPNLPGSARIPPISLDSAGGARQAKRPTLQSRATSGSA | ||||||
Domain | 700-736 | Cyclic nucleotide-binding | ||||
Sequence: DMKDDVEIVFFPKGSVLVEQGERNPGLYYVVDGFLDI | ||||||
Domain | 842-962 | Cyclic nucleotide-binding | ||||
Sequence: RLTSLLPRLIMHIDFALDWEQVDAGQVLFHEGEESEAIHIVLNGRLRLVQDRKDGGVSVRAEFGQGESVGELEVLTESVRPGTLHAIRQTELVKFPRTLFNSLAQEHPNITIKISKIIASR | ||||||
Domain | 1221-1385 | PNPLA | ||||
Sequence: LVLGGGGARGFTQIGIIQAMEESGIPIDVVGGTSIGAFIGALYARHADVVPIFGLAKKFAGRMSSMWRLALDLTYPTASYTTGHEFNRGIFKTFGKAQIEDFWLEFYCNTTNISKSRIEYHTSGYAWRYIRASMSLAGLLPPLCDEGSMLLDGGYIDNLTVSHMK | ||||||
Motif | 1225-1230 | GXGXXG | ||||
Sequence: GGGARG | ||||||
Motif | 1252-1256 | GXSXG | ||||
Sequence: GTSIG | ||||||
Motif | 1372-1374 | DGA/G | ||||
Sequence: DGG |
Sequence similarities
Belongs to the NTE family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,524
- Mass (Da)167,805
- Last updated2012-03-21 v1
- ChecksumA0CD6AF2A9AEAA55
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CACQ02007501 EMBL· GenBank· DDBJ | CCF45178.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LTAN01000003 EMBL· GenBank· DDBJ | OBR12516.1 EMBL· GenBank· DDBJ | Genomic DNA |