H1VY66 · H1VY66_COLHI

Function

function

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium.

Catalytic activity

Features

Showing features for active site.

115242004006008001,0001,2001,400
TypeIDPosition(s)Description
Active site1254Nucleophile
Active site1372Proton acceptor

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionlysophospholipase activity
Biological Processphosphatidylcholine catabolic process
Biological Processregulation of phospholipid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lysophospholipase NTE1
  • EC number
  • Alternative names
    • Intracellular phospholipase B

Gene names

    • ORF names
      CH063_03530
      , CH63R_04812

Organism names

Accessions

  • Primary accession
    H1VY66

Proteomes

Organism-specific databases

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane51-71Helical
Transmembrane92-114Helical

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, domain, motif.

TypeIDPosition(s)Description
Region221-246Disordered
Region279-381Disordered
Domain700-736Cyclic nucleotide-binding
Domain842-962Cyclic nucleotide-binding
Domain1221-1385PNPLA
Motif1225-1230GXGXXG
Motif1252-1256GXSXG
Motif1372-1374DGA/G

Sequence similarities

Belongs to the NTE family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,524
  • Mass (Da)
    167,805
  • Last updated
    2012-03-21 v1
  • Checksum
    A0CD6AF2A9AEAA55
MSSSDISSAAHAVSESLSATMNASPDAALPSAFTRAQEVVAAQGSSSWLGLFGRLILAILSLVSSILYWAIRIVTITIPTVLFTLFSTSWTVTMNATTLMVIVVAIISAVSWVVRYRILNMYSRLPPEPQRKEPDVDLFPDTHDEGKKSGLSSYLDEFLSAIKIFGYLERQVFHELTRSMQTRKLIAGETFNLEEEKGFCIVVDGLVEIFVKSGRIARAMDTDPCDSYGADSADAGEEEDMSSPHGQQRYQLLTEVRNGAPMSSLFSIMSLFTEDVKLRSTDDETPESTASSAGLRTSPFPRNAGFRRMPSDPVSPFPATPEFPESTEERPGVRIEEPPRRAATPNLPGSARIPPISLDSAGGARQAKRPTLQSRATSGSAHPDIIARATVDTTIAIIPASAFRRLTKVYPKATSHIVQVILSRFQRVTLATAYNYLGLTGEVLQTEKNMLSFTTCQLPNMLRGDALQRLKEKFDRERERVGGESESKGIALHNANAHRRRKSTPTLRKDAMIHSMATKERSFSQVATTIAPPRERASTHTPSPGDLLANIQSARYGGHRPSGASSVHLDQVADALRHEGVSPLAQRSFNPFTTERHSRVSVDGRESLDEDNLFRQSILECMFKAIGLSSNGSVSREAESVEGSPRLFSYDQTRPRQGLGNNAFGLMGPFDASGDGDTESMTSGGFTLNTPPNAHILANDMKDDVEIVFFPKGSVLVEQGERNPGLYYVVDGFLDICTSKEDTSADILQSSSRTSLHADYTGVDGSPGFSDNADSRKKTPYRRSVSLIKPGGLAGYVGTVSSYRSFIDVVAKTDVYVGFLPRSALERIVDRYPIVLLTMAKRLTSLLPRLIMHIDFALDWEQVDAGQVLFHEGEESEAIHIVLNGRLRLVQDRKDGGVSVRAEFGQGESVGELEVLTESVRPGTLHAIRQTELVKFPRTLFNSLAQEHPNITIKISKIIASRMRNLVDDPSQLLSKEAGNTNTITKGSSSLNLRTVAILPVTSGVPVVEFGNRLMNALAQVGPANGATSLNQSAILNHLGKHAFNKMGKLKLSQYLADLEEKYGLVVYVADTNVNSPWTQTCITQADCILLVGLAEGSPEIGEYERFMLGMKSTARKLLVLLHPERYSQSGLTRAWLRNRMWINGGHYHVQMPLGPNILPVHPPSKRTSTTLKERVQIIQAEIQKYTSRKTRHSAFYSPDAPYKGDFHRLARRLCGKSIGLVLGGGGARGFTQIGIIQAMEESGIPIDVVGGTSIGAFIGALYARHADVVPIFGLAKKFAGRMSSMWRLALDLTYPTASYTTGHEFNRGIFKTFGKAQIEDFWLEFYCNTTNISKSRIEYHTSGYAWRYIRASMSLAGLLPPLCDEGSMLLDGGYIDNLTVSHMKRLGVDTIFSIDVGSLDDDTPQTYGDSLSGVWAFWNRWNPFSVTPNPPTLAEIQARLAYVSSVDALERAKMMPGCFYMRPPIDDYGTLDFGKFDELYQMGYKYGQDFLQKLRDDGALPFMEETEAKKAMRRTMAPRRASI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CACQ02007501
EMBL· GenBank· DDBJ
CCF45178.1
EMBL· GenBank· DDBJ
Genomic DNA
LTAN01000003
EMBL· GenBank· DDBJ
OBR12516.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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