H1VW32 · H1VW32_COLHI

Function

function

DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site, dna binding.

1838100200300400500600700800
TypeIDPosition(s)Description
Binding site340-347ATP (UniProtKB | ChEBI)
DNA binding742-761

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromosome, telomeric repeat region
Cellular Componentmitochondrion
Cellular Componentnucleolus
Cellular ComponentrDNA heterochromatin
Cellular Componentsite of double-strand break
Molecular Function5'-3' DNA helicase activity
Molecular Function5'-3' DNA/RNA helicase activity
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent protein-DNA complex displacement activity
Molecular FunctionDNA/DNA annealing activity
Molecular Functionflap-structured DNA binding
Molecular FunctionG-quadruplex DNA binding
Molecular FunctionRNA binding
Molecular Functionsingle-stranded DNA helicase activity
Biological ProcessDNA recombination
Biological ProcessDNA strand elongation involved in mitotic DNA replication
Biological ProcessG-quadruplex DNA unwinding
Biological Processmitochondrial DNA repair
Biological Processmitotic recombination-dependent replication fork processing
Biological Processremoval of RNA primer involved in mitotic DNA replication
Biological Processtelomere maintenance

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent DNA helicase PIF1
  • EC number
  • Alternative names
    • DNA repair and recombination helicase PIF1

Gene names

    • Name
      PIF1
    • ORF names
      CH063_00064

Organism names

Accessions

  • Primary accession
    H1VW32

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-129Disordered
Compositional bias22-109Polar residues
Region144-264Disordered
Compositional bias157-171Pro residues
Compositional bias181-213Polar residues
Compositional bias229-246Basic and acidic residues
Domain332-501AAA+ ATPase

Sequence similarities

Belongs to the helicase family. PIF1 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    838
  • Mass (Da)
    92,444
  • Last updated
    2012-03-21 v1
  • Checksum
    F56BC0B30CEF6012
MLARANKAYEASAPPPKNDLAKQLFPSSSPSATQNGNIMDQFKKTSQPISNAPVSARTASTTNTSMPSKSSRPPPGRTASVTHFANSNRSVLDSLSAPNGRSLASLYSRSDSFRHEPETSLSVQNQSANSKPVVYFAEDDFSDDDQLDLDYEAPSALPSLPKPPSKAVKVPEPPIEEPLSQFVPWSSSPASHFVNPKLSRTTSATSSLKRDSPENAESLAALQPKKRRLPKNWSFEEEDRTPVPESEPEVPRWAPGGVTPAPKKETWNMTASAVKEQKKQLKTQSKKAMAGDEWTMDEIRQEVTQSNLPRPKASAIALTKEQKHVQSLVVNKGQSVFFTGPAGTGKSVLMRSIIAELKKKWARDPERLAVTASTGLAACNIGGQTLHSFAGIGLGKDDIPTLVKKIRRNPKAKNRWLRTKTLIIDEVSMVDGELFDKLSSIGRTIRNNGKPWGGIQLVITGDFFQLPPVPDGDKSRESKFAFEAATWNTAIDHTIGLTQVFRQRDPVFANMLNEMRLGKISEETVQAFRKLTRPIVSDDGLEVTELFPTRYEVENANQGRLRSLPGKTYRFDAADSGDPQVRDKLLQNMMAAKTIDLKVGAQVMLIKNMDDTLVNGSLGKVTRFMSEGSFESWHMTDYGSDVDASEEGDLKRKIKAFSREVEEATKGTTEFPVVEFAAVDGSTRTILCVPEDWKVETPTGEVQASRSQLPLILAWALSIHKAQGQTLERVKVDLGKVFEKGQAYVALSRATSQQGLQVLRFQKDKVMAHPRVVGFYNKLYSAEQAVAKKPPSMADFLHKEEDTKLVKANARSQSFVRKGVEVIDLDYEEEAMASYGNF

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias22-109Polar residues
Compositional bias157-171Pro residues
Compositional bias181-213Polar residues
Compositional bias229-246Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CACQ02006902
EMBL· GenBank· DDBJ
CCF44443.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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