H1UX49 · H1UX49_COLHI

Function

function

Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentnucleus
Cellular ComponentTORC1 complex
Cellular ComponentTORC2 complex
Molecular FunctionATP binding
Molecular Functionhistone H2AS1 kinase activity
Molecular Functionprotein-containing complex binding
Biological Processnegative regulation of macroautophagy
Biological Processprotein phosphorylation
Biological ProcessTOR signaling

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    non-specific serine/threonine protein kinase
  • EC number

Gene names

    • ORF names
      CH063_00117
      , CH63R_06911

Organism names

Accessions

  • Primary accession
    H1UX49

Proteomes

Organism-specific databases

Subcellular Location

Interaction

Subunit

Associates with DNA double-strand breaks.

Protein-protein interaction databases

Family & Domains

Features

Showing features for repeat, domain, region.

Type
IDPosition(s)Description
Repeat705-737HEAT
Domain1246-1841FAT
Domain2016-2331PI3K/PI4K catalytic
Region2296-2322Disordered
Region2334-2357Disordered
Domain2400-2432FATC

Sequence similarities

Belongs to the PI3/PI4-kinase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,432
  • Mass (Da)
    275,847
  • Last updated
    2012-03-21 v1
  • Checksum
    CE1528CEB69FEF89
MATQQQIALERLDNLVRDLRSRTSDDVRKRAALQLRELVLVCHRDLPLEQFNTIYGHVNNKITQLISHGNDSSERLGGVYALDALVDIEVSEQSTKMFARFNQNLKTILRGKDINPMQAAAIALGKMCRPGGSMISELVESETQMALEWLQSERVEERRYSAALVLRELARQAPTLMYNYVGLVLDLIWNSLRDNRHLIRATSAETVAACFRIIRERDQELKQTWMEKAYAELLRGLQHGTVEYIHASLLMLKELLEQGGMFMQDHYPEACEIVLRYKDHRDVTIRKTVVLLIPDLASYSPAEFDRSYLHKFMVYLSGMLKKDKERNDAFLAIGNIANSVKSAIAPYLDGVMTHVREGLSLAARKRGPVDAVFECISRLAVAVGQTLSKYMEALLDPIFECDLTPKLTQALVDMAFYIPPAKDTIQNRLLDMLSMVLCGEPFKPLGAPHPNTLQAVPAVPKDSKDPLAYEHRKAEVKLALNTLGSFDFTGHVLNEFVRDVAVKYVEDEDPETREAAALTCCQLYVRDPIVNQTSYHALQVVGDVIERLLTVGVSDPEPNIRRTVLAALDERFDRHLAKAENIRTLFFALNDEVFAIREVAISIIGRLARYNPAYVIPSLRKTLIQLLTELEFSDVARNKEESAKLLSLLVQNAQGLVKPYVDPMMSVLLPKANDPSAAVAATILRAIGELATVGGEEVLPYKDRLMPLIIEALQDQSSNNKREAALHALGQLASNSGYVIEPYLEYPQLLELLQGIIRTEGQRGPLRQETIKLMGILGALDPYKYQQVEQRRPDAQRRVESTQMTDISLMMTGLTPSSKEYFPTVVINALLQILKDNSLSSHHASVIEAIMNIFRTLGLECVSFLDRIIPAFLGVIRAADKTRLDSYFSQLATLVSIVRQHIRNFLPEIVEICQEFWNTTSTLQSTIMNLVEAISRSLEGEFKIYLAGLLPLMLGVLEKDTTTRRTPSEKVLHAFLVFGSSAEEYMHLIIPVIVRTFEKQGQPSPLRKQAIETIGKITYQVNLNDYAAKIIHPLTRILGSGDITLRVAALDTLCALIQQLGKDYLHFMGTVNKVLAQHQIQHQNYDLLVTKLQKGEVLPQDLGSGDRFVDRVDDQAAFADLGAKKLEMNAIHLKQAWDTKGKSTKEDWQEWLRRFSTTLLTESPNHALRACAALASSYLPLARELFNSAFVSCWSELYEQFQDELIQNIESAIKSENVPPDLLGLLLNLAEFMEHDDKALPIDIRVLGREAARCHAYAKALHYKELEFLQDQSSGAVEALIVINNQLQQSDAAIGILRKAQLYKEGIQLRETWFEKLERWEEALAFYTKREMEVPDDKPVPVEIIMGKMRCLHALGEWEALAGIAGNTWANSSPDVQRLIAPLATAAAWGLSKWDSMDNYLQSMKRYSTDRSFFGAILALHRNQFREAVNCVQQAREGLDTELSALVSESYNRAYQVVVRVQMLAELEELIVYKQTDDKKKATMRRTWETRLKGCQRNVEVWQRMLRLRHLVISPTENMHMWIKFANLCRKSGRMGLAEKSLKQLIGVEQTPLETLIPYWNERQQPNAAVPRNIPSQVIYAMLKYEWEVGQQPAFRTSGISERTLYCLRKFTNDSAHRYEATKAHLTSQAPNGMDLSSEYGFPHQIDPSLMNPQTQKALYDQTVLLAKCYLRQGEWHIALNKENWQYEHVQDILTSYSQATKYNPRWYKAWHAWALANFEIVQALSTRGERTDHMVIEHVVPAVRGFFKSIALSAGSSLQDTLRLLTLWFTHGASADVNAAVTEGFTNVSVDTWLEVIPQLIARINQPTRRVQQSIHSLLADVGRAHPQALVYPLTVAMKSSQNSRRSRSAAQIMDSMRQHSANLVSQADVVSHELIRVAVLWHEQWHEGLEEASRLYFGDHNIEGMFATLEPLHDQLERGPETLREISFTQAFGRDLTEAREWCRQYEASRDVNDLNQAWDLYYQVFRRISRQLPQLTTLELPYCSPKLLAAKDLDLAVPGTYRSGQPIVRIMEFEGTFTVINSKQRPRKLNISGSDGVSYAFLLKGHEDIRQDERVMQLFGLCNTLLSNDSECYKRHLNIQRYPAIPLSQNSGLLGWVPNSDTLHVLIREYRESRKILLNIEHRIMLQMAPDYDNLTLMQKVEVFGYALDNTTGQDLYRVLWLKSKSSEAWLERRTNYTRSLGVMSMVGYILGLGDRHPSNLMLDRVTGKIIHIDFGDCFEVAMKREKYPERVPFRLTRMLTYAMEVSNIEGSFRITCEHVMRVLRDNKDSVMAVLEAFIHDPLLTWRLTNAASPTGPNFRSERETALAGPQAARARRPSVLDSDIAPSELLAAGDPAMPGGPVARSRSRTNSSMAHDGSVVNGNHGQDPTEIQNARAVEVLDRVSQKLTGKDFKPNEELDVINQVNKLITEATKLENLCQHYIGWCSFW

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CACQ02000458
EMBL· GenBank· DDBJ
CCF32550.1
EMBL· GenBank· DDBJ
Genomic DNA
LTAN01000004
EMBL· GenBank· DDBJ
OBR11219.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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