H1UX49 · H1UX49_COLHI
- Proteinnon-specific serine/threonine protein kinase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids2432 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.
Catalytic activity
- L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Cellular Component | TORC1 complex | |
Cellular Component | TORC2 complex | |
Molecular Function | ATP binding | |
Molecular Function | histone H2AS1 kinase activity | |
Molecular Function | protein-containing complex binding | |
Biological Process | negative regulation of macroautophagy | |
Biological Process | protein phosphorylation | |
Biological Process | TOR signaling |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namenon-specific serine/threonine protein kinase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Glomerellales > Glomerellaceae > Colletotrichum > Colletotrichum destructivum species complex
Accessions
- Primary accessionH1UX49
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Structure
Family & Domains
Features
Showing features for repeat, domain, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Repeat | 705-737 | HEAT | |||
Domain | 1246-1841 | FAT | |||
Domain | 2016-2331 | PI3K/PI4K catalytic | |||
Region | 2296-2322 | Disordered | |||
Region | 2334-2357 | Disordered | |||
Domain | 2400-2432 | FATC | |||
Sequence similarities
Belongs to the PI3/PI4-kinase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,432
- Mass (Da)275,847
- Last updated2012-03-21 v1
- ChecksumCE1528CEB69FEF89
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CACQ02000458 EMBL· GenBank· DDBJ | CCF32550.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LTAN01000004 EMBL· GenBank· DDBJ | OBR11219.1 EMBL· GenBank· DDBJ | Genomic DNA |