H1KXL9 · H1KXL9_9EURY
- ProteinMethyl-coenzyme M reductase subunit beta
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids444 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
function
Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
Catalytic activity
- coenzyme B + methyl-coenzyme M = coenzyme M-coenzyme B heterodisulfide + methaneThis reaction proceeds in the forward direction.
Cofactor
Pathway
One-carbon metabolism; methyl-coenzyme M reduction; methane from methyl-coenzyme M: step 1/1.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | coenzyme-B sulfoethylthiotransferase activity | |
Biological Process | methanogenesis |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMethyl-coenzyme M reductase subunit beta
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageArchaea > Euryarchaeota > Methanomada group > Methanococci > Methanococcales > Methanocaldococcaceae > Methanotorris
Accessions
- Primary accessionH1KXL9
Proteomes
Interaction
Subunit
Hexamer of two alpha, two beta, and two gamma chains.
MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 6-187 | Methyl-coenzyme M reductase beta subunit N-terminal | ||||
Sequence: DKICLYNAKGELVEENVPLEAISPLYNPTIQKLVKDIKRTVAVNLAGIENALKTGAVGGKACVIPGRTLDLPIVENAETIMEYVDKLLRISPDDDTSVKLINDGKQMAVQLPSKRLEVAAEYSISMLNTAMALKEAIIKTFDVDMFDAPMVHAAILGRYPQVPDYMGANIASLLGAPTNLEG | ||||||
Domain | 189-437 | Methyl-coenzyme M reductase beta subunit C-terminal | ||||
Sequence: GYALRNIMVNHYVATTKKNIMNAVAFASIMEQTAMFEMGDAIGSFERLHLLGLAYQGLNADNLVIDLVKANGKNGTVGTVVASIVERALEDGVITEDKKMPSGFVLYKPVDVAKWNAYAAAGLVAAVIVNCGAARAAQNVASTILYYNDIIEYETGLPGVDFGRAEGTAVGFSFFSHSIYGGGGPGIFNGNHIVTRHSKGFAIPPVCAAMCVDAGTQMFSPEKTSALVGAVFSAIDEFREPLKYVIDGA |
Sequence similarities
Belongs to the methyl-coenzyme M reductase beta subunit family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length444
- Mass (Da)47,497
- Last updated2012-03-21 v1
- Checksum6D6163917A4BBFB7
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AGJL01000010 EMBL· GenBank· DDBJ | EHP88092.1 EMBL· GenBank· DDBJ | Genomic DNA |