H1KSU3 · H1KSU3_METEX

Function

function

Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site83Zn2+ (UniProtKB | ChEBI)
Binding site241Zn2+ (UniProtKB | ChEBI)
Binding site245Zn2+ (UniProtKB | ChEBI)
Active site268Proton donor

GO annotations

AspectTerm
Molecular Functionmetal ion binding
Molecular FunctionUDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Molecular FunctionUDP-3-O-acyl-N-acetylglucosamine deacetylase activity
Biological Processlipid A biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    UDP-3-O-acyl-N-acetylglucosamine deacetylase
  • EC number
  • Short names
    UDP-3-O-acyl-GlcNAc deacetylase
  • Alternative names
    • UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase

Gene names

    • Name
      lpxC
    • ORF names
      MetexDRAFT_5706

Organism names

  • Taxonomic identifier
  • Strain
    • DSM 13060
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Methylobacteriaceae > Methylorubrum

Accessions

  • Primary accession
    H1KSU3

Proteomes

Family & Domains

Sequence similarities

Belongs to the LpxC family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    315
  • Mass (Da)
    33,837
  • Last updated
    2012-03-21 v1
  • Checksum
    4EEBD4270A8B2D5D
MRTNQQTTLKTSVTLTGIGVHSGNPAEITLHPAKANHGIAFLRTGTTTGNDRIIKAHFACVSATELCTVIGDVETGAVATIEHLMSALYGLGVDNALVEIDGPEMPILDGSARLFVQAIDSVGLALCRAPRRWIKVLQPVRIEAGRAFAELRPIDRGFRLDVEIDFESPVIGRSRKAMDLTPAAYRREIAPARTFGMMKDVERYWKAGFALGASLDNTVAVGETAVVNPEGLRFADEFVRHKFLDAVGDLALAGLPLQGAYRSYCGGHRMNVGILEALFADRANYAIVEGQGTRRETARADFGAGLGLAAFAAEL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AGJK01000290
EMBL· GenBank· DDBJ
EHP86671.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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