H1KGR6 · H1KGR6_METEX
- ProteinDiaminopimelate epimerase
- GenedapF
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids296 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
Catalytic activity
- (2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate
Pathway
Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.
Features
Showing features for binding site, active site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 17 | substrate | ||||
Sequence: N | ||||||
Binding site | 49 | substrate | ||||
Sequence: Q | ||||||
Binding site | 69 | substrate | ||||
Sequence: N | ||||||
Active site | 78 | |||||
Sequence: C | ||||||
Active site | 78 | Proton donor | ||||
Sequence: C | ||||||
Binding site | 79-80 | substrate | ||||
Sequence: GN | ||||||
Binding site | 171 | substrate | ||||
Sequence: N | ||||||
Site | 173 | Could be important to modulate the pK values of the two catalytic cysteine residues | ||||
Sequence: H | ||||||
Binding site | 205 | substrate | ||||
Sequence: N | ||||||
Site | 223 | Could be important to modulate the pK values of the two catalytic cysteine residues | ||||
Sequence: E | ||||||
Binding site | 223-224 | substrate | ||||
Sequence: ER | ||||||
Active site | 232 | Proton acceptor | ||||
Sequence: C | ||||||
Binding site | 233-234 | substrate | ||||
Sequence: GT |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | diaminopimelate epimerase activity | |
Biological Process | lysine biosynthetic process via diaminopimelate |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDiaminopimelate epimerase
- EC number
- Short namesDAP epimerase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Methylobacteriaceae > Methylorubrum
Accessions
- Primary accessionH1KGR6
Proteomes
Subcellular Location
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length296
- Mass (Da)31,924
- Last updated2012-03-21 v1
- Checksum0407EF203B8BD0AB
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AGJK01000035 EMBL· GenBank· DDBJ | EHP93303.1 EMBL· GenBank· DDBJ | Genomic DNA |