H1KGR6 · H1KGR6_METEX

Function

function

Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.

Features

Showing features for binding site, active site, site.

TypeIDPosition(s)Description
Binding site17substrate
Binding site49substrate
Binding site69substrate
Active site78
Active site78Proton donor
Binding site79-80substrate
Binding site171substrate
Site173Could be important to modulate the pK values of the two catalytic cysteine residues
Binding site205substrate
Site223Could be important to modulate the pK values of the two catalytic cysteine residues
Binding site223-224substrate
Active site232Proton acceptor
Binding site233-234substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functiondiaminopimelate epimerase activity
Biological Processlysine biosynthetic process via diaminopimelate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Diaminopimelate epimerase
  • EC number
  • Short names
    DAP epimerase
  • Alternative names
    • PLP-independent amino acid racemase

Gene names

    • Name
      dapF
    • ORF names
      MetexDRAFT_1828

Organism names

  • Taxonomic identifier
  • Strain
    • DSM 13060
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Methylobacteriaceae > Methylorubrum

Accessions

  • Primary accession
    H1KGR6

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the diaminopimelate epimerase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    296
  • Mass (Da)
    31,924
  • Last updated
    2012-03-21 v1
  • Checksum
    0407EF203B8BD0AB
MSPLANRRFLKMHGAGNAIVVLDLRGTAVRVTPAEARAIAADVHSRFDQLMVVHDPVTPCTDAFMRIYNTDGSESGACGNGTRCVGYALLDDPAMARPAENGALTLETKAGLVAVKRITERSFTVDMGQPRLRWDEIPLAEPFLDTRRIELQVGPIDDPILHSPAAVSMGNPHAIFFVERDPDSYDLGRIGPLLEAHPIFPERANISIAEVTSRDTIKLRVWERGAGLTLACGTAACATVVAASRLRMIGRTARVALPGGELSIEWRADDHVLMTGPVYLEGEGTFSPDLFAGIDG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AGJK01000035
EMBL· GenBank· DDBJ
EHP93303.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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