H1KE76 · H1KE76_METEX

Function

function

Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

tRNA modification; tRNA-queuosine biosynthesis.

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site51Thioimide intermediate
Active site58Proton donor
Binding site73-75substrate
Binding site92-93substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionpreQ1 synthase activity
Biological Processqueuosine biosynthetic process
Biological ProcesstRNA modification

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADPH-dependent 7-cyano-7-deazaguanine reductase
  • EC number
  • Alternative names
    • 7-cyano-7-carbaguanine reductase
    • NADPH-dependent nitrile oxidoreductase
    • PreQ(0) reductase

Gene names

    • Name
      queF
    • ORF names
      MetexDRAFT_0938

Organism names

  • Taxonomic identifier
  • Strain
    • DSM 13060
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Methylobacteriaceae > Methylorubrum

Accessions

  • Primary accession
    H1KE76

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for compositional bias, region.

TypeIDPosition(s)Description
Compositional bias1-20Polar residues
Region1-30Disordered

Sequence similarities

Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    153
  • Mass (Da)
    17,119
  • Last updated
    2012-03-21 v1
  • Checksum
    81380DD3012D5344
MDSIETHAKQLGQQTPLPASPEAAQLDRVPNPHADTDYLARFTAPEFTSLCPVTGQPDFATLVIDYVPDRWLVESKSLKLYLGAFRNHGAFHEDCTVGIGRRLVALLEPRWLRIGGYWYPRGGIPIDVFWQTGEPLKSVWLPDQGVASYRGRG

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-20Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AGJK01000014
EMBL· GenBank· DDBJ
EHP94193.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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