H0ZXQ4 · H0ZXQ4_TAEGU
- ProteinHistone deacetylase 3
- GeneHDAC3
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids458 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
Catalytic activity
- N6-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 93 | substrate | |||
Active site | 135 | Proton acceptor | |||
Binding site | 143 | substrate | |||
Binding site | 170 | a divalent metal cation (UniProtKB | ChEBI) | |||
Binding site | 172 | a divalent metal cation (UniProtKB | ChEBI) | |||
Binding site | 289 | a divalent metal cation (UniProtKB | ChEBI) | |||
Binding site | 328 | substrate | |||
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHistone deacetylase 3
- EC number
- Short namesHD3
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Passeriformes > Passeroidea > Estrildidae > Estrildinae > Taeniopygia
Accessions
- Primary accessionH0ZXQ4
Proteomes
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 22-231 | Histone deacetylase | |||
Domain | 260-342 | Histone deacetylase | |||
Compositional bias | 415-435 | Basic and acidic residues | |||
Region | 415-458 | Disordered | |||
Compositional bias | 441-458 | Basic and acidic residues | |||
Sequence similarities
Belongs to the histone deacetylase family. HD Type 1 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length458
- Mass (Da)52,190
- Last updated2020-06-17 v2
- MD5 Checksum50B1A1E014520FA6253C2829DED94DDD
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A674GVK4 | A0A674GVK4_TAEGU | HDAC3 | 441 | ||
A0A674HVS7 | A0A674HVS7_TAEGU | HDAC3 | 405 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 415-435 | Basic and acidic residues | |||
Compositional bias | 441-458 | Basic and acidic residues | |||
Keywords
- Technical term