H0ZXQ4 · H0ZXQ4_TAEGU

Function

function

Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.

Catalytic activity

Features

Showing features for binding site, active site.

145850100150200250300350400450
Type
IDPosition(s)Description
Binding site93substrate
Active site135Proton acceptor
Binding site143substrate
Binding site170a divalent metal cation (UniProtKB | ChEBI)
Binding site172a divalent metal cation (UniProtKB | ChEBI)
Binding site289a divalent metal cation (UniProtKB | ChEBI)
Binding site328substrate

GO annotations

AspectTerm
Cellular Componentchromatin
Cellular Componentcytosol
Cellular ComponentGolgi apparatus
Cellular Componenthistone deacetylase complex
Cellular Componentmitotic spindle
Cellular Componentplasma membrane
Cellular Componenttranscription repressor complex
Molecular Functionchromatin DNA binding
Molecular Functioncyclin binding
Molecular Functionhistone deacetylase activity
Molecular Functionhistone deacetylase binding
Molecular Functionhistone decrotonylase activity
Molecular Functionmetal ion binding
Molecular FunctionNF-kappaB binding
Molecular Functionprotein de-2-hydroxyisobutyrylase activity
Molecular Functiontranscription corepressor activity
Molecular Functiontranscription corepressor binding
Biological Processcellular response to fluid shear stress
Biological Processcircadian regulation of gene expression
Biological Processcornified envelope assembly
Biological ProcessDNA repair-dependent chromatin remodeling
Biological Processestablishment of mitotic spindle orientation
Biological Processestablishment of skin barrier
Biological Processin utero embryonic development
Biological Processnegative regulation of cardiac muscle cell differentiation
Biological Processnegative regulation of JNK cascade
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processneural precursor cell proliferation
Biological Processpositive regulation of cold-induced thermogenesis
Biological Processpositive regulation of protein import into nucleus
Biological Processpositive regulation of protein phosphorylation
Biological Processpositive regulation of protein ubiquitination
Biological Processpositive regulation of TOR signaling
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processprotein deacetylation
Biological Processrandom inactivation of X chromosome
Biological Processregulation of circadian rhythm
Biological Processregulation of mitotic cell cycle
Biological Processregulation of multicellular organism growth
Biological Processregulation of protein stability
Biological Processspindle assembly
Biological Processtranscription by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Histone deacetylase 3
  • EC number
  • Short names
    HD3

Gene names

    • Name
      HDAC3

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Passeriformes > Passeroidea > Estrildidae > Estrildinae > Taeniopygia

Accessions

  • Primary accession
    H0ZXQ4

Proteomes

Subcellular Location

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, compositional bias, region.

Type
IDPosition(s)Description
Domain22-231Histone deacetylase
Domain260-342Histone deacetylase
Compositional bias415-435Basic and acidic residues
Region415-458Disordered
Compositional bias441-458Basic and acidic residues

Sequence similarities

Belongs to the histone deacetylase family. HD Type 1 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    458
  • Mass (Da)
    52,190
  • Last updated
    2020-06-17 v2
  • MD5 Checksum
    50B1A1E014520FA6253C2829DED94DDD
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPNNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSRCSLPFPLGPRGFLVLLFKSHDNSTSLSKGYKHLFQPVINQVVDYYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVDEPISDELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPSDLLSYDRTDEPDPEERGSEENYTRPEAPNEFYDGDHDNDKESDVEI

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A674GVK4A0A674GVK4_TAEGUHDAC3441
A0A674HVS7A0A674HVS7_TAEGUHDAC3405

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias415-435Basic and acidic residues
Compositional bias441-458Basic and acidic residues

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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