H0ZML2 · H0ZML2_TAEGU
- ProteinPlasminogen
- GeneLOC100231371
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids802 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.
Catalytic activity
Activity regulation
Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 158 | L-lysine (UniProtKB | ChEBI) | |||
Binding site | 172 | L-lysine (UniProtKB | ChEBI) | |||
Binding site | 429 | L-lysine (UniProtKB | ChEBI) | |||
Binding site | 442 | L-lysine (UniProtKB | ChEBI) | |||
Active site | 614 | Charge relay system | |||
Active site | 657 | Charge relay system | |||
Active site | 752 | Charge relay system | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular space | |
Molecular Function | serine-type endopeptidase activity | |
Molecular Function | signaling receptor binding | |
Biological Process | blood coagulation | |
Biological Process | fibrinolysis | |
Biological Process | proteolysis | |
Biological Process | tissue remodeling |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePlasminogen
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Passeriformes > Passeroidea > Estrildidae > Estrildinae > Taeniopygia
Accessions
- Primary accessionH0ZML2
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-19 | ||||
Chain | PRO_5025329216 | 20-802 | Plasminogen | ||
Disulfide bond | 185↔262 | ||||
Disulfide bond | 206↔245 | ||||
Disulfide bond | 234↔257 | ||||
Disulfide bond | 275↔352 | ||||
Disulfide bond | 296↔335 | ||||
Disulfide bond | 324↔347 | ||||
Disulfide bond | 374↔451 | ||||
Disulfide bond | 395↔434 | ||||
Disulfide bond | 423↔446 | ||||
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 20-98 | Apple | |||
Domain | 102-181 | Kringle | |||
Domain | 184-262 | Kringle | |||
Domain | 274-352 | Kringle | |||
Compositional bias | 294-308 | Polar residues | |||
Region | 294-313 | Disordered | |||
Domain | 373-451 | Kringle | |||
Domain | 472-552 | Kringle | |||
Domain | 573-800 | Peptidase S1 | |||
Sequence similarities
Belongs to the peptidase S1 family. Plasminogen subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length802
- Mass (Da)90,670
- Last updated2020-06-17 v2
- MD5 Checksum3FE929CB6E1AA0544377217B698D8647
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 294-308 | Polar residues | |||
Keywords
- Technical term