H0YMQ9 · H0YMQ9_HUMAN
- ProteinSolute carrier family 12 (Potassium/chloride transporters), member 6, isoform CRA_c
- GeneSLC12A6
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids906 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
Catalytic activity
- chloride(in) + K+(in) = chloride(out) + K+(out)
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | potassium:chloride symporter activity |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionH0YMQ9
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 186-206 | Helical | ||||
Sequence: GTFMGVYLPCLQNIFGVILFL | ||||||
Transmembrane | 212-234 | Helical | ||||
Sequence: VGTAGVLQAFAIVLICCCCTMLT | ||||||
Transmembrane | 272-297 | Helical | ||||
Sequence: FYLGTTFAAAMYILGAIEIFLVYIVP | ||||||
Transmembrane | 318-337 | Helical | ||||
Sequence: MRVYGTAFLVLMVLVVFIGV | ||||||
Transmembrane | 343-362 | Helical | ||||
Sequence: FASLFLACVIVSILAIYAGA | ||||||
Transmembrane | 476-496 | Helical | ||||
Sequence: YVLVDITTSFTLLVGIFFPSV | ||||||
Transmembrane | 516-542 | Helical | ||||
Sequence: IPIGTILAILTTSFVYLSNVVLFGACI | ||||||
Transmembrane | 621-639 | Helical | ||||
Sequence: WALLLTAAIAELGILIASL | ||||||
Transmembrane | 645-666 | Helical | ||||
Sequence: ILSMFFLMCYLFVNLACALQTL | ||||||
Transmembrane | 678-695 | Helical | ||||
Sequence: YYHWALSFMGMSICLALM | ||||||
Transmembrane | 883-905 | Helical | ||||
Sequence: FLRATLMCGGLCMMGGCLCYYHS |
Keywords
- Cellular component
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 756 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
PTM/Processing
Features
Showing features for modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Modified residue (large scale data) | 29 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 31 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 32 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 37 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 93 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 96 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 120 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 148 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 156 | PRIDE | Phosphotyrosine | ||||
Sequence: Y |
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 20-66 | Disordered | ||||
Sequence: TKIDDIPGLSDTSPDLSSRSSSRVRFSSRESVPETSRSEPMSEMSGA | ||||||
Compositional bias | 30-66 | Polar residues | ||||
Sequence: DTSPDLSSRSSSRVRFSSRESVPETSRSEPMSEMSGA | ||||||
Region | 161-181 | Disordered | ||||
Sequence: QGAKEHEEAENITEGKKKPTK | ||||||
Compositional bias | 163-177 | Basic and acidic residues | ||||
Sequence: AKEHEEAENITEGKK | ||||||
Domain | 191-363 | Amino acid permease/ SLC12A | ||||
Sequence: VYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAI | ||||||
Domain | 482-760 | Amino acid permease/ SLC12A | ||||
Sequence: TTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLL | ||||||
Domain | 774-878 | SLC12A transporter C-terminal | ||||
Sequence: PRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIA |
Sequence similarities
Belongs to the SLC12A transporter family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length906
- Mass (Da)99,266
- Last updated2012-02-22 v1
- Checksum20D65B400C1997D6
Computationally mapped potential isoform sequences
There are 7 potential isoforms mapped to this entry
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 30-66 | Polar residues | ||||
Sequence: DTSPDLSSRSSSRVRFSSRESVPETSRSEPMSEMSGA | ||||||
Compositional bias | 163-177 | Basic and acidic residues | ||||
Sequence: AKEHEEAENITEGKK |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC021822 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC079203 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471125 EMBL· GenBank· DDBJ | EAW92298.1 EMBL· GenBank· DDBJ | Genomic DNA |