H0YJR5 · H0YJR5_HUMAN
- ProteinGephyrin
- GeneGPHN
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids201 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.
Catalytic activity
- ATP + H+ + molybdopterin = adenylyl-molybdopterin + diphosphate
- adenylyl-molybdopterin + molybdate = AMP + H+ + Mo-molybdopterin
Cofactor
Pathway
Cofactor biosynthesis; molybdopterin biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | molybdopterin adenylyltransferase activity | |
Molecular Function | molybdopterin molybdotransferase activity | |
Biological Process | Mo-molybdopterin cofactor biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGephyrin
Including 2 domains:
- Recommended nameMolybdopterin molybdenumtransferase
- EC number
- Short namesMPT Mo-transferase
- Alternative names
- Recommended nameMolybdopterin adenylyltransferase
- EC number
- Short namesMPT adenylyltransferase
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionH0YJR5
Proteomes
Organism-specific databases
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 150 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 27-170 | MoaB/Mog | ||||
Sequence: AVMSTGNELLNPEDDLLPGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNEGISRADVIITSGGVSMGEKDYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALPGNPVSAVVTCNLFVVPALRK |
Sequence similarities
Belongs to the MoeA family.
In the N-terminal section; belongs to the MoaB/Mog family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusFragment
- Length201
- Mass (Da)21,699
- Last updated2012-02-22 v1
- Checksum7C0060C55BA1CEB3
Computationally mapped potential isoform sequences
There are 8 potential isoforms mapped to this entry
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: H |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL049835 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL117667 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL133241 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL139295 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL159179 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL355093 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
KF455914 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
KF510140 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |