H0YJF7 · H0YJF7_HUMAN
- Proteinnon-specific serine/threonine protein kinase
- GeneVRK1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids420 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | nucleolus | |
Cellular Component | nucleoplasm | |
Molecular Function | ATP binding | |
Molecular Function | protein serine/threonine kinase activity | |
Biological Process | protein phosphorylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namenon-specific serine/threonine protein kinase
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionH0YJF7
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Modified residue (large scale data) | 13 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 342 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 376 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 378 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 398 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 400 | PRIDE | Phosphoserine | ||||
Sequence: S |
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 37-317 | Protein kinase | ||||
Sequence: WKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLY | ||||||
Region | 354-420 | Disordered | ||||
Sequence: ITKKRKKEIEESKEPGVEDTEWSNTQTEEAIQTRSEESQGAIHRSMSQPEASSSSYDSSRTRKRVQK | ||||||
Compositional bias | 356-371 | Basic and acidic residues | ||||
Sequence: KKRKKEIEESKEPGVE | ||||||
Compositional bias | 372-412 | Polar residues | ||||
Sequence: DTEWSNTQTEEAIQTRSEESQGAIHRSMSQPEASSSSYDSS |
Sequence similarities
Belongs to the protein kinase superfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length420
- Mass (Da)48,016
- Last updated2021-06-02 v2
- ChecksumD842EF012F2CE3A3
Computationally mapped potential isoform sequences
There are 37 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q99986 | VRK1_HUMAN | VRK1 | 396 | ||
H0YJJ9 | H0YJJ9_HUMAN | VRK1 | 394 | ||
H0YJ50 | H0YJ50_HUMAN | VRK1 | 228 | ||
A0A7P0T9E5 | A0A7P0T9E5_HUMAN | VRK1 | 395 | ||
A0A7P0T9I1 | A0A7P0T9I1_HUMAN | VRK1 | 372 | ||
A0A7P0T9T1 | A0A7P0T9T1_HUMAN | VRK1 | 394 | ||
A0A7P0T8M0 | A0A7P0T8M0_HUMAN | VRK1 | 101 | ||
A0A7P0T925 | A0A7P0T925_HUMAN | VRK1 | 314 | ||
A0A7P0T8N0 | A0A7P0T8N0_HUMAN | VRK1 | 356 | ||
A0A7P0T952 | A0A7P0T952_HUMAN | VRK1 | 393 | ||
A0A7P0T977 | A0A7P0T977_HUMAN | VRK1 | 362 | ||
A0A7P0T8Z5 | A0A7P0T8Z5_HUMAN | VRK1 | 99 | ||
A0A7P0T9C6 | A0A7P0T9C6_HUMAN | VRK1 | 302 | ||
A0A7P0T9B1 | A0A7P0T9B1_HUMAN | VRK1 | 172 | ||
A0A7P0T838 | A0A7P0T838_HUMAN | VRK1 | 395 | ||
A0A7P0T824 | A0A7P0T824_HUMAN | VRK1 | 444 | ||
A0A7P0T832 | A0A7P0T832_HUMAN | VRK1 | 170 | ||
A0A7P0T833 | A0A7P0T833_HUMAN | VRK1 | 46 | ||
A0A7P0T814 | A0A7P0T814_HUMAN | VRK1 | 249 | ||
A0A7P0TBB8 | A0A7P0TBB8_HUMAN | VRK1 | 375 | ||
A0A7P0TBE4 | A0A7P0TBE4_HUMAN | VRK1 | 413 | ||
A0A7P0TBI6 | A0A7P0TBI6_HUMAN | VRK1 | 321 | ||
A0A7P0TA65 | A0A7P0TA65_HUMAN | VRK1 | 393 | ||
A0A7P0TAA6 | A0A7P0TAA6_HUMAN | VRK1 | 437 | ||
A0A7P0TAI5 | A0A7P0TAI5_HUMAN | VRK1 | 83 | ||
A0A7P0TB08 | A0A7P0TB08_HUMAN | VRK1 | 244 | ||
A0A7P0TAS8 | A0A7P0TAS8_HUMAN | VRK1 | 403 | ||
A0A7P0TB37 | A0A7P0TB37_HUMAN | VRK1 | 52 | ||
A0A7P0TB15 | A0A7P0TB15_HUMAN | VRK1 | 394 | ||
A0A7P0TA07 | A0A7P0TA07_HUMAN | VRK1 | 72 | ||
A0A7P0TA16 | A0A7P0TA16_HUMAN | VRK1 | 442 | ||
A0A7P0Z4P9 | A0A7P0Z4P9_HUMAN | VRK1 | 81 | ||
A0A7P0Z3Z7 | A0A7P0Z3Z7_HUMAN | VRK1 | 395 | ||
A0A7P0Z445 | A0A7P0Z445_HUMAN | VRK1 | 448 | ||
A0A7P0Z462 | A0A7P0Z462_HUMAN | VRK1 | 395 | ||
A0A7P0Z4C8 | A0A7P0Z4C8_HUMAN | VRK1 | 161 | ||
A0A7P0Z4A4 | A0A7P0Z4A4_HUMAN | VRK1 | 366 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 356-371 | Basic and acidic residues | ||||
Sequence: KKRKKEIEESKEPGVE | ||||||
Compositional bias | 372-412 | Polar residues | ||||
Sequence: DTEWSNTQTEEAIQTRSEESQGAIHRSMSQPEASSSSYDSS |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL133168 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471061 EMBL· GenBank· DDBJ | EAW81654.1 EMBL· GenBank· DDBJ | Genomic DNA |