H0YI98 · H0YI98_HUMAN
- ProteinDynactin subunit 2
- GeneDCTN2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids268 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
function
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length. Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | dynactin complex | |
Cellular Component | dynein complex | |
Biological Process | microtubule-based process |
Names & Taxonomy
Protein names
- Recommended nameDynactin subunit 2
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionH0YI98
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for modified residue (large scale data).
Type | ID | Position(s) | Source | Description | ||
---|---|---|---|---|---|---|
Modified residue (large scale data) | 11 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 18 | PRIDE | Phosphothreonine | |||
Modified residue (large scale data) | 82 | PRIDE | Phosphothreonine | |||
Modified residue (large scale data) | 91 | PRIDE | Phosphotyrosine | |||
Modified residue (large scale data) | 180 | PRIDE | Phosphotyrosine | |||
Modified residue (large scale data) | 187 | PRIDE | Phosphoserine | |||
Proteomic databases
Expression
Gene expression databases
Interaction
Subunit
Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters and consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin. Interacts with BICD2 and CEP135. Interacts with DYNAP. Interacts with ECPAS. Interacts with MAPRE1.
Structure
Sequence
- Sequence statusFragment
- Length268
- Mass (Da)29,327
- Last updated2012-02-22 v1
- MD5 Checksum6FD4417B06956C23D4E8B40DE151A8F1
Computationally mapped potential isoform sequences
There are 13 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q13561 | DCTN2_HUMAN | DCTN2 | 401 | ||
H0YHL1 | H0YHL1_HUMAN | DCTN2 | 128 | ||
F8VX93 | F8VX93_HUMAN | DCTN2 | 37 | ||
F8VW18 | F8VW18_HUMAN | DCTN2 | 278 | ||
F8VRV7 | F8VRV7_HUMAN | DCTN2 | 152 | ||
F8W0U6 | F8W0U6_HUMAN | DCTN2 | 45 | ||
F8W1I6 | F8W1I6_HUMAN | DCTN2 | 315 | ||
A8K8J9 | A8K8J9_HUMAN | DCTN2 | 314 | ||
A0A7I2V2Z2 | A0A7I2V2Z2_HUMAN | DCTN2 | 107 | ||
A0A7I2V390 | A0A7I2V390_HUMAN | DCTN2 | 296 | ||
A0A7I2V4H4 | A0A7I2V4H4_HUMAN | DCTN2 | 379 | ||
A0A7I2V4Y9 | A0A7I2V4Y9_HUMAN | DCTN2 | 378 | ||
A0A7I2V5R4 | A0A7I2V5R4_HUMAN | DCTN2 | 76 |
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC022506 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |