H0YEI2 · H0YEI2_HUMAN
- ProteinAdenine DNA glycosylase
- GeneMUTYH
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids386 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
Catalytic activity
Cofactor
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | DNA binding | |
Molecular Function | hydrolase activity, acting on glycosyl bonds | |
Molecular Function | metal ion binding | |
Biological Process | base-excision repair |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAdenine DNA glycosylase
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionH0YEI2
Proteomes
Organism-specific databases
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-38 | Disordered | ||||
Sequence: MRKPRAAVGSGHRKQAASQEGRQKHAKNNSQAKPSACD | ||||||
Compositional bias | 22-36 | Polar residues | ||||
Sequence: RQKHAKNNSQAKPSA | ||||||
Domain | 108-260 | HhH-GPD | ||||
Sequence: MLQQTQVATVINYYTGWMQKWPTLQDLASASLEEVNQLWAGLGYYSRGRRLQEGARKVVEELGGHMPRTAETLQQLLPGVGRYTAGAIASIAFGQATGVVDGNVARVLCRVRAIGADPSSTLVSQQLWGLAQQLVDPARPGDFNQAAMELGAT | ||||||
Region | 329-349 | Disordered | ||||
Sequence: GTRPWEWSTSPERPAASPPGR |
Sequence similarities
Belongs to the Nth/MutY family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length386
- Mass (Da)42,405
- Last updated2024-01-24 v2
- ChecksumE87F33640DB73723
Computationally mapped potential isoform sequences
There are 21 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q9UIF7 | MUTYH_HUMAN | MUTYH | 546 | ||
A0AAQ5BGW7 | A0AAQ5BGW7_HUMAN | MUTYH | 528 | ||
A0A6Q8PF38 | A0A6Q8PF38_HUMAN | MUTYH | 47 | ||
H0YER6 | H0YER6_HUMAN | MUTYH | 97 | ||
H0YCY5 | H0YCY5_HUMAN | MUTYH | 472 | ||
H0YCA8 | H0YCA8_HUMAN | MUTYH | 478 | ||
Q5T413 | Q5T413_HUMAN | MUTYH | 291 | ||
Q5T418 | Q5T418_HUMAN | MUTYH | 393 | ||
E5KP25 | E5KP25_HUMAN | MUTYH | 549 | ||
A0A5F9ZHI2 | A0A5F9ZHI2_HUMAN | MUTYH | 212 | ||
A0A5F9ZI14 | A0A5F9ZI14_HUMAN | MUTYH | 466 | ||
A0A5F9ZI60 | A0A5F9ZI60_HUMAN | MUTYH | 209 | ||
E9PNY0 | E9PNY0_HUMAN | MUTYH | 216 | ||
E9PP30 | E9PP30_HUMAN | MUTYH | 45 | ||
E9PP34 | E9PP34_HUMAN | MUTYH | 527 | ||
E9PLT4 | E9PLT4_HUMAN | MUTYH | 62 | ||
E9PM53 | E9PM53_HUMAN | MUTYH | 535 | ||
E9PMH1 | E9PMH1_HUMAN | MUTYH | 185 | ||
E9PIW5 | E9PIW5_HUMAN | MUTYH | 40 | ||
E9PKM9 | E9PKM9_HUMAN | MUTYH | 55 | ||
E9PI11 | E9PI11_HUMAN | MUTYH | 54 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 22-36 | Polar residues | ||||
Sequence: RQKHAKNNSQAKPSA |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL359540 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |