H0Y5L2 · H0Y5L2_HUMAN
- ProteinEthylmalonyl-CoA decarboxylase
- GeneECHDC1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids341 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
function
Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Acts preferentially on (S)-ethylmalonyl-CoA but has also some activity on the (R)-isomer. Also has methylmalonyl-CoA decarboxylase activity at lower level.
Catalytic activity
- (2R)-ethylmalonyl-CoA + H+ = butanoyl-CoA + CO2This reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | catalytic activity |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameEthylmalonyl-CoA decarboxylase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionH0Y5L2
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Disease & Variants
Variants
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The viewer provides 311 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
PTM/Processing
Features
Showing features for modified residue (large scale data).
Type | ID | Position(s) | Source | Description | ||
---|---|---|---|---|---|---|
Modified residue (large scale data) | 48 | PRIDE | Phosphoserine | |||
Proteomic databases
Expression
Gene expression databases
Sequence
- Sequence statusComplete
- Length341
- Mass (Da)37,789
- Last updated2022-12-14 v2
- Checksum35DBEA5CF7131175
Computationally mapped potential isoform sequences
There are 11 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q9NTX5 | ECHD1_HUMAN | ECHDC1 | 307 | ||
J3KP84 | J3KP84_HUMAN | ECHDC1 | 125 | ||
H0YCS9 | H0YCS9_HUMAN | ECHDC1 | 100 | ||
H0YD54 | H0YD54_HUMAN | ECHDC1 | 34 | ||
H0Y525 | H0Y525_HUMAN | ECHDC1 | 76 | ||
E9PRU6 | E9PRU6_HUMAN | ECHDC1 | 135 | ||
E9PPG7 | E9PPG7_HUMAN | ECHDC1 | 125 | ||
E9PLY6 | E9PLY6_HUMAN | ECHDC1 | 179 | ||
E9PIU8 | E9PIU8_HUMAN | ECHDC1 | 83 | ||
E9PJS8 | E9PJS8_HUMAN | ECHDC1 | 151 | ||
F2Z2D6 | F2Z2D6_HUMAN | ECHDC1 | 139 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL109939 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |