H0Y5L2 · H0Y5L2_HUMAN

  • Protein
    Ethylmalonyl-CoA decarboxylase
  • Gene
    ECHDC1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    2/5

Function

function

Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Acts preferentially on (S)-ethylmalonyl-CoA but has also some activity on the (R)-isomer. Also has methylmalonyl-CoA decarboxylase activity at lower level.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functioncatalytic activity

Keywords

  • Molecular function

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ethylmalonyl-CoA decarboxylase
  • EC number
  • Alternative names
    • Enoyl-CoA hydratase domain-containing protein 1
    • Methylmalonyl-CoA decarboxylase

Gene names

    • Name
      ECHDC1

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    H0Y5L2

Proteomes

Organism-specific databases

Subcellular Location

Disease & Variants

Variants

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The viewer provides 311 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Genetic variation databases

PTM/Processing

Features

Showing features for modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Modified residue (large scale data)48PRIDEPhosphoserine

Proteomic databases

Expression

Gene expression databases

Structure

3D structure databases

Family & Domains

Sequence similarities

Belongs to the enoyl-CoA hydratase/isomerase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    341
  • Mass (Da)
    37,789
  • Last updated
    2022-12-14 v2
  • Checksum
    35DBEA5CF7131175
MAKSLLKTASLSGRTKLLHQTGLSLYSTSHGFYEEEVKKTLQQFPGGSIDLQKEDNGIGILTLNNPSRMNAFSGVMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPEESCRWNTEFLYTLHPVSPFINILYSYGWNGRMHVHAKHLNKIYEVKKQRGKILLGLSRLPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRFVHKEMGIIPSWGGTTRLVEIIGSRQALKVLSGALKLDSKNALNIGMVEEVLQSSDETKSLEEAQEWLKQFIQGPPEVIRALKKSVCSGRELYLEEALQNERDLLGTVWGGPANLEAIAKKGKFNK

Computationally mapped potential isoform sequences

There are 11 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q9NTX5ECHD1_HUMANECHDC1307
J3KP84J3KP84_HUMANECHDC1125
H0YCS9H0YCS9_HUMANECHDC1100
H0YD54H0YD54_HUMANECHDC134
H0Y525H0Y525_HUMANECHDC176
E9PRU6E9PRU6_HUMANECHDC1135
E9PPG7E9PPG7_HUMANECHDC1125
E9PLY6E9PLY6_HUMANECHDC1179
E9PIU8E9PIU8_HUMANECHDC183
E9PJS8E9PJS8_HUMANECHDC1151
F2Z2D6F2Z2D6_HUMANECHDC1139

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL109939
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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