H0XA80 · H0XA80_OTOGA
- ProteinBiotinidase
- GeneBTD
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids530 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation.
Catalytic activity
- biocytin + H2O = biotin + L-lysine
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 99 | Proton acceptor | ||||
Sequence: E | ||||||
Active site | 199 | Proton donor | ||||
Sequence: K | ||||||
Active site | 232 | Nucleophile | ||||
Sequence: C |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Molecular Function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | |
Biological Process | biotin metabolic process |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBiotinidase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Strepsirrhini > Lorisiformes > Galagidae > Otolemur
Accessions
- Primary accessionH0XA80
Proteomes
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-31 | |||||
Sequence: SRFMVCTMSGASSKLALFLCGCYVVALGVHA | ||||||
Chain | PRO_5003545354 | 32-530 | Biotinidase | |||
Sequence: REHCVAGHHEAEYYMAAVFEHQSILSPDPLALTNRKQALELMNQNLDIYEQQVMAAAQKGVQIIVFPEDGIHGFNFTRTSIYPFLDFMPSPQLVRWNPCLEPHRFNDTEVLQRLSCMAIKGEMFLVANLGTKQPCHSNDPGCPNDGRYQFNTNVVFSSNGTLVDRYRKHNLYFEAAFDSPLKVDLITFDTPFAGKFGIFTCFDILFFFPAVSLLRDSEVKHIVYPTAWMNQLPLLAAIEIQKAFAVAFGVSVLAANIHHPSLGMTGSGIHTPRKSFLYHDMENPKGHLIIAQVAKNPQSLIGTENATGKGDPSHSKFLKILSGDPYCEKDAQEVHCDGATTWNMNAPPIFHSEMMYDNFTLVPVWGKEGYLQVCSNGLCCYLLYKRPTLSQELYALGVFDGLHTVHGTYYIQVCALVKCGGLGFDTCGQEITEATGIFEFHLWGNFSTSYIFPLFLTSGMTLEIPDQLGWENDHYFLRKSGLSSGLVTAALYGRLYERD |
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 59-338 | CN hydrolase | ||||
Sequence: DPLALTNRKQALELMNQNLDIYEQQVMAAAQKGVQIIVFPEDGIHGFNFTRTSIYPFLDFMPSPQLVRWNPCLEPHRFNDTEVLQRLSCMAIKGEMFLVANLGTKQPCHSNDPGCPNDGRYQFNTNVVFSSNGTLVDRYRKHNLYFEAAFDSPLKVDLITFDTPFAGKFGIFTCFDILFFFPAVSLLRDSEVKHIVYPTAWMNQLPLLAAIEIQKAFAVAFGVSVLAANIHHPSLGMTGSGIHTPRKSFLYHDMENPKGHLIIAQVAKNPQSLIGTENAT | ||||||
Coiled coil | 63-90 | |||||
Sequence: LTNRKQALELMNQNLDIYEQQVMAAAQK |
Sequence similarities
Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length530
- Mass (Da)59,204
- Last updated2012-02-22 v1
- Checksum1E86B5F92D9AAEF4
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AAQR03004775 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AAQR03004776 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |