H0WZC0 · H0WZC0_OTOGA

Function

function

Proteolytically removes the C-terminal three residues of farnesylated proteins.

Catalytic activity

  • Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic side chains and P3' is any C-terminal residue.
    EC:3.4.24.84 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

147850100150200250300350400450
TypeIDPosition(s)Description
Binding site338Zn2+ (UniProtKB | ChEBI); catalytic
Active site339
Binding site342Zn2+ (UniProtKB | ChEBI); catalytic
Binding site418Zn2+ (UniProtKB | ChEBI); catalytic
Active site422Proton donor

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular Componentnuclear envelope
Cellular Componentprotein-containing complex
Molecular Functiondouble-stranded DNA binding
Molecular Functionmetal ion binding
Molecular Functionmetalloendopeptidase activity
Biological Processadult walking behavior
Biological Processbone mineralization
Biological ProcessCAAX-box protein processing
Biological Processcalcium ion import into sarcoplasmic reticulum
Biological ProcessCAMKK-AMPK signaling cascade
Biological Processcardiac conduction
Biological Processcardiac muscle cell development
Biological Processcardiac ventricle development
Biological Processcellular lipid metabolic process
Biological Processcellular response to gamma radiation
Biological Processdetermination of adult lifespan
Biological ProcessDNA repair
Biological Processgrowth plate cartilage development
Biological Processhair follicle development
Biological Processheart morphogenesis
Biological Processinflammatory cell apoptotic process
Biological Processkidney morphogenesis
Biological Processliver development
Biological Processmaintenance of rDNA
Biological Processmulticellular organism growth
Biological Processnegative regulation of miRNA processing
Biological Processneuromuscular process
Biological Processnuclear envelope organization
Biological Processpositive regulation of gene expression via chromosomal CpG island demethylation
Biological Processprenylated protein catabolic process
Biological Processregulation of autophagy
Biological Processregulation of bone mineralization
Biological Processregulation of cell shape
Biological Processregulation of cellular senescence
Biological Processregulation of defense response to virus
Biological Processregulation of DNA damage response, signal transduction by p53 class mediator
Biological Processregulation of fibroblast proliferation
Biological Processregulation of glucose metabolic process
Biological Processregulation of hormone metabolic process
Biological Processregulation of lipid metabolic process
Biological Processregulation of mitotic cell cycle DNA replication
Biological Processregulation of multicellular organism growth
Biological Processregulation of stress-activated protein kinase signaling cascade
Biological Processregulation of termination of RNA polymerase I transcription
Biological Processregulation of TOR signaling
Biological Processregulation of ventricular cardiac muscle cell membrane repolarization
Biological Processresponse to DNA damage checkpoint signaling
Biological Processthymus development
Biological Processventricular cardiac muscle tissue development

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    CAAX prenyl protease
  • EC number

Gene names

    • Name
      ZMPSTE24

Organism names

Accessions

  • Primary accession
    H0WZC0

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane20-38Helical
Transmembrane77-102Helical
Transmembrane122-144Helical
Transmembrane171-189Helical
Transmembrane195-216Helical
Transmembrane360-382Helical
Transmembrane388-413Helical

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain41-225CAAX prenyl protease 1 N-terminal
Domain229-474Peptidase M48
Region304-325Disordered

Sequence similarities

Belongs to the peptidase M48A family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    478
  • Mass (Da)
    55,019
  • Last updated
    2012-02-22 v1
  • Checksum
    A605FF931BF0107D
MGMWASLDAMWEMPAEKRIFGAVLLFSWTVYLWETFLAQRQRRIYKTTTHVPPELGQIMDSETFEKSRLYQLDKSTFSFWSGLYSEIEGTLILLFGGIPYLWRLSGRFCGYAGFGSEYEITQSLVFLLLATLFSALTGLPWSLYNTFVIEEKHGFNQQTLGFFMKDAIKKFIVTQCILLPVSSLLLYIIKIGGDYFFIYAWLFTLVVSLVLVTIYADYIAPLFDKFTPLPEGKLKQEIEVMAKSIDFPLTKVYVVEGKAACGYICIYTLGYNNNDGCKGLIFQSSQIYYFIPQKDNKDTSFLVPPNNNDGYNQKKKKKKKRNKKQGCKNEEVLAVLGHELGHWKLGHTVKNIIISQMNSFLCFFLFAILIGRKELFAAFGFYDSQPTLIGLLIIFQFIFSPYNEVLSFCLTVLSRRFEFQADAFAKKLGKAKDLYSALIKLNKDNLGFPVSDWLFSMWHYSHPPLLERLQALKSSKQD

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAQR03149788
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AAQR03149789
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AAQR03149790
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AAQR03149791
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AAQR03149792
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AAQR03149793
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AAQR03149794
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AAQR03149795
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AAQR03149796
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

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