H0WG15 · H0WG15_OTOGA

Function

function

Exhibits palmitoyl protein thioesterase (S-depalmitoylation) activity in vitro and most likely plays a role in protein S-depalmitoylation.

Catalytic activity

  • 2 3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) = 3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(3'-(9Z-octadecenoyl)-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol)
    This reaction proceeds in the forward direction.
  • 2 3-hexadecanoyl-sn-glycero-1-phospho-(1'-sn-glycerol) = 3-hexadecanoyl-sn-glycero-1-phospho-(3'-hexadecanoyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol)
    This reaction proceeds in the forward direction.
  • 2 3-octadecanoyl-sn-glycero-1-phospho-(1'-sn-glycerol) = 3-octadecanoyl-sn-glycero-1-phospho-(3'-octadecanoyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol)
    This reaction proceeds in the forward direction.
  • 2 3-tetradecanoyl-sn-glycero-1-phospho-(1'-sn-glycerol) = 3-tetradecanoyl-sn-glycero-1-phospho-(3'-tetradecanoyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol)
    This reaction proceeds in the forward direction.
  • 2 a 3-acyl-sn-glycero-1-phospho-(1'-sn-glycerol) = a 3-acyl-sn-glycero-1-phospho-(3'-acyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol)
    This reaction proceeds in the forward direction.
  • H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H+ + hexadecanoate + L-cysteinyl-[protein]
    This reaction proceeds in the forward direction.
    EC:3.1.2.22 (UniProtKB | ENZYME | Rhea)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentendoplasmic reticulum
Cellular ComponentGolgi apparatus
Cellular Componentlysosomal membrane
Cellular Componentperinuclear region of cytoplasm
Cellular Componentvacuolar lumen
Molecular Functionbis(monoacylglycero)phosphate synthase activity
Molecular FunctionD-mannose binding
Molecular Functionhydrolase activity, acting on glycosyl bonds
Molecular Functionlong-chain fatty acyl-CoA hydrolase activity
Biological Processbrain development
Biological Processglycosylation
Biological Processlysosomal lumen acidification
Biological Processneurogenesis
Biological Processretrograde transport, endosome to Golgi
Biological Processsignal peptide processing
Biological Processvisual perception

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Bis(monoacylglycero)phosphate synthase CLN5
  • EC number
  • Alternative names
    • Ceroid-lipofuscinosis neuronal protein 5
    • Palmitoyl protein thioesterase CLN5
    • S-depalmitoylase CLN5

Gene names

    • Name
      CLN5

Organism names

Accessions

  • Primary accession
    H0WG15

Proteomes

PTM/Processing

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-20Disordered

Sequence similarities

Belongs to the CLN5 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    359
  • Mass (Da)
    41,547
  • Last updated
    2012-02-22 v1
  • Checksum
    B517F8A989164490
MAQSGDTGPESEGRRGAGADPRRRSWRWALTLFWLAAAGPGWPRASGGAPRHHWPVPYKRFSFRPDPDPFCQAKYTFCPTGSPIPVLKGDDVIEVFRLQTPVWEFKYGNLLGHLKIMHDAIGFRSTLTGKNYTVEWYELFQLGNCTFPHLRPEMNAPFWCNQGAACFFEGIDDIHWKENGTLVLIATISGNMFNEMAKWIKQDNETGIYYETWTVQASPEKGAETWFESYDCSKFVLRTYKKLAELGAEFKKIETNYTRIFLYSGEPTYLGNETSVFGPAGNKTLALAIKKFYYPFKPHLSTKEFLLSLLQIFDTVIIHRQFYLFYNFEYWFLPMKFPFIKITYEEIPLPTRNRTLPGL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAQR03067861
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

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