H0WA27 · H0WA27_CAVPO

Function

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Activity regulation

Activated by threonine and tyrosine phosphorylation.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site85ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular ComponentPML body
Molecular FunctionATP binding
Molecular FunctionMAP kinase activity
Molecular Functionmitogen-activated protein kinase binding
Molecular Functionprotein serine kinase activity
Biological Processcalcineurin-NFAT signaling cascade
Biological Processcellular response to hydrogen peroxide
Biological Processcellular response to laminar fluid shear stress
Biological Processcellular response to transforming growth factor beta stimulus
Biological Processnegative regulation of calcineurin-NFAT signaling cascade
Biological Processnegative regulation of endothelial cell apoptotic process
Biological Processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Biological Processnegative regulation of heterotypic cell-cell adhesion
Biological Processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
Biological Processnegative regulation of response to cytokine stimulus
Biological Processpositive regulation of protein metabolic process
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processprotein phosphorylation
Biological Processregulation of angiogenesis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Mitogen-activated protein kinase
  • EC number

Gene names

    • Name
      MAPK7

Organism names

  • Taxonomic identifier
  • Strain
    • 2N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Hystricomorpha > Caviidae > Cavia

Accessions

  • Primary accession
    H0WA27

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for compositional bias, region, domain.

Type
IDPosition(s)Description
Compositional bias1-15Basic and acidic residues
Region1-28Disordered
Domain55-337Protein kinase
Region392-719Disordered
Compositional bias419-454Pro residues
Compositional bias496-535Basic and acidic residues
Compositional bias568-587Polar residues
Compositional bias613-631Pro residues
Compositional bias635-649Polar residues
Compositional bias665-682Pro residues
Compositional bias683-703Polar residues

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    797
  • Mass (Da)
    86,743
  • Last updated
    2017-11-22 v2
  • Checksum
    E5FE8F2897A4E28A
MAEPLKEEDGEDGSGEPPGPAKAEPSHTTASVAAKNLALLKARSFDVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILKPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLFMMVLGTPSPAVIQAVGAERVRPVPWETVYPGADRQTLSLQICMQRFEPRARICAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEPGCPDVEMPSPWAPSGDCAMESPPPVPPPCTGPAPDSVDLTLQPPPPASEPAPPKREGAISDNTKAALKATLLKSLRSRLRDGPSVPLEAPEPRKPVTAQERQREREEKRRRRQERAKEREKRRQERERKERGAGTLGGPSTDPLAGLVLSDNDRSLLERWTRMGPAPCPTSSSSPSTNTIPSTAHSPPIGPVAQPTGPPLQLASSTPIPASQPACSPPASHPAGPPGPISVPASLQTAPSTSLLAPPSLVPASGLPGPSTAVLPYFPSGPPPPDPGGLPQPSTSESPDVNLVTQQLSKSQVEDPLPPVFSGTPKGSGAGYGVGFDLEEFLNQSFDMGVADGPQDGQADSASLSASLLADWLEGHGMNPADIESLQREIQMDSPMLLSDLPDLQEP

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A286XH34A0A286XH34_CAVPOMAPK7728
A0A286XHP6A0A286XHP6_CAVPOMAPK7350

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-15Basic and acidic residues
Compositional bias419-454Pro residues
Compositional bias496-535Basic and acidic residues
Compositional bias568-587Polar residues
Compositional bias613-631Pro residues
Compositional bias635-649Polar residues
Compositional bias665-682Pro residues
Compositional bias683-703Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAKN02046455
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help