H0VKP5 · H0VKP5_CAVPO

Function

function

Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.

Catalytic activity

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site80Proton acceptor
Active site179Proton donor
Active site212Nucleophile

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Cellular Componentside of membrane
Molecular Functionpantetheine hydrolase activity
Biological Processacute inflammatory response
Biological Processcell-cell adhesion
Biological Processchronic inflammatory response
Biological Processcoenzyme A catabolic process
Biological Processinnate immune response
Biological Processpantothenate metabolic process
Biological Processpositive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
Biological Processpositive regulation of T cell differentiation in thymus

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Pantetheinase
  • EC number
  • Alternative names
    • Pantetheine hydrolase
    • Vascular non-inflammatory molecule 1

Gene names

    • Name
      VNN1

Organism names

  • Taxonomic identifier
  • Strain
    • 2N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Hystricomorpha > Caviidae > Cavia

Accessions

  • Primary accession
    H0VKP5

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Lipid-anchor, GPI-anchor
Membrane
; Lipid-anchor, GPI-anchor

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-23
ChainPRO_500354325224-513Pantetheinase

Keywords

Expression

Gene expression databases

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain31-307CN hydrolase

Sequence similarities

Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    513
  • Mass (Da)
    57,393
  • Last updated
    2012-02-22 v1
  • Checksum
    9AA78A0CC51AABFD
MIPSQLLVSATFLVFCFLKVSSSATFTAAVYEHAVILPNVTLTPVSSEEALALMNRNLDLLEAAIISAAKQGAQIIVTPEDGIYGMIFTRTSIYSYLEDIPDPQVNWIPCDNPNRFGLAPVQRRLSCLAKGNAIYVVANIGDKKPCNTSDPQCPPDGRYQYNTNVVFDSQGKLVARYHKRHLFMNEDQFDTPKEAEVVTFDTAFGKFGIFTCFDVLFHDPAVMLVKDSHVDTVLFPTAWMNVLPHLSAVEFHSAWAMGMGVNFLASNLHNPLLRMTGSGIYAPDSPRKFHYDMETQEGKLLVSQLDSHPYRPEVNWTSYASSIEAFSVRNQEFKGTVFYDEYIFVELKGITGNYTVCQKDLCCHLSYQMSEKRSDEVYALGAFDGLHTAEGQYYLQVCTLLKCKTTNVQSCGDSVDTAATRFEMFSLSGTFGTQYVFPEVLLSEVQLAPREFQVMSDGRLQSLQPTSRPLLTVTLFGRFYDRDGLRDASIDLGAHALRGLVMVLMPILYALCW

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAKN02045635
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

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