H0FCZ7 · H0FCZ7_9BURK

Function

function

Catalyzes the reduction of the glycolytic intermediate dihydroxyacetone phosphate (DHAP) to sn-glycerol 3-phosphate (G3P), the key precursor for phospholipid synthesis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Membrane lipid metabolism; glycerophospholipid metabolism.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site15-20NAD+ (UniProtKB | ChEBI)
Binding site18NADPH (UniProtKB | ChEBI)
Binding site19NADPH (UniProtKB | ChEBI)
Binding site38NADPH (UniProtKB | ChEBI)
Binding site55NADPH (UniProtKB | ChEBI)
Binding site122NADPH (UniProtKB | ChEBI)
Binding site122sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site122substrate
Binding site150sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site152sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site154NAD+ (UniProtKB | ChEBI)
Binding site154NADPH (UniProtKB | ChEBI)
Active site205Proton acceptor
Binding site205sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site258sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site268sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site269NAD+ (UniProtKB | ChEBI)
Binding site269NADPH (UniProtKB | ChEBI)
Binding site269sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site269-270substrate
Binding site270sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site294NADPH (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionglycerol-3-phosphate dehydrogenase (NADP+) activity
Molecular Functionglycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Molecular FunctionNAD binding
Biological Processcarbohydrate metabolic process
Biological Processglycerol-3-phosphate biosynthetic process
Biological Processglycerol-3-phosphate catabolic process
Biological Processglycerophospholipid metabolic process
Biological Processphospholipid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glycerol-3-phosphate dehydrogenase [NAD(P)+]
  • EC number
  • Alternative names
    • NAD(P)(+)-dependent glycerol-3-phosphate dehydrogenase
    • NAD(P)H-dependent dihydroxyacetone-phosphate reductase

Gene names

    • Name
      gpsA
    • ORF names
      KYC_23283

Organism names

Accessions

  • Primary accession
    H0FCZ7

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-24
ChainPRO_500353334925-359Glycerol-3-phosphate dehydrogenase [NAD(P)+]

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain11-172Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Domain194-333Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    359
  • Mass (Da)
    36,608
  • Last updated
    2012-02-22 v1
  • Checksum
    B6FE4F684AA51779
MNPPAPPRLRVAVLGAGSWGTALAAAASRRHPTQLWARDAAQAASMAATHENARYLPGVSLPKNLQFSSDLDATLRCLQDDGGHRLIVLGVPVAGLTAICDELSRRLPALGLEDTPIVWTCKGFEADTARLPHEIMREALPGATGGALSGPSFAREVAQGLPVALTVASSSPALRDATTAAFHGAALRVYASTDLIGVEVGGALKNVIAVACGICDGLALGTNARAALITRGLAEMTRFGVALGAQAETFAGLTGLGDLVLTATGELSRNRRVGLEIGAGRKLADILASGITAEGVRCARAALERARAINVELPITEAVCAVLFDGVAPMTAVSALLARDARNEGADSGNPLQGPSGPA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AGUF01000074
EMBL· GenBank· DDBJ
EHK63790.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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