G9ZJX0 · G9ZJX0_9LACO

Function

function

Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster per subunit.

Pathway

Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site333[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site393[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site396[4Fe-4S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function3-isopropylmalate dehydratase activity
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionmetal ion binding
Biological ProcessL-leucine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    3-isopropylmalate dehydratase large subunit
  • EC number
  • Alternative names
    • Alpha-IPM isomerase
      (IPMI
      )
    • Isopropylmalate isomerase

Gene names

    • Name
      leuC
    • ORF names
      HMPREF9103_00016

Organism names

Accessions

  • Primary accession
    G9ZJX0

Proteomes

Interaction

Subunit

Heterodimer of LeuC and LeuD.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-443Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha

Sequence similarities

Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    453
  • Mass (Da)
    49,601
  • Last updated
    2012-02-22 v1
  • MD5 Checksum
    B7FF0BCB432AB87325546FFE22A2A6AE
MFDKIWDKHVITGEPGEPQLIYVDLQLVHEVTSPQAFEGLRENHRKVRRPDKTFATMDHNVPTKDIFNVQDAIARKQIDTLKKNTDEFGVRLAGMGDEDQGIVHVIGPQLGLTQPGMVIVCGDSHTSTHGAFGSIAFGIGTSEVEHVLATQTIWQTKPKTMGIHVHGKLPKGVFAKDIIMGIIAQEGVAFGVGYAAEFYGDTIRDMSMEGRMTICNMAVEGGAKMGNIQPDQKTFDYVSGRKYAPKNMAKAIEYWKQFTTDDESAYDKIIDFDVSDLAPYVSWGTNPGMAIPVTGDFPAIKDEDDQKAYDYIGLKPGDKPKDIPIQWAFFGSCTNGRLSDLKIAAQYMKGHHIANGVTAWVVPGSRTVKEQAEKIGIDQIFKDAGCEWREPGCSACLAMNPDQVPAGVHCASTTNRNFEGRQGVGARTHLASPAMVAAAAINGHFVDIRKEQI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AGEY01000002
EMBL· GenBank· DDBJ
EHM01619.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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