G9KLM5 · G9KLM5_MUSPF
- Proteinnon-specific serine/threonine protein kinase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1343 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Cofactor
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytoskeleton | |
Cellular Component | nucleus | |
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | protein serine/threonine kinase activity | |
Molecular Function | small GTPase binding | |
Biological Process | actin cytoskeleton organization | |
Biological Process | positive regulation of centrosome duplication | |
Biological Process | regulation of actin cytoskeleton organization | |
Biological Process | Rho protein signal transduction | |
Biological Process | rhythmic process | |
Biological Process | smooth muscle contraction |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namenon-specific serine/threonine protein kinase
- EC number
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Musteloidea > Mustelidae > Mustelinae > Mustela
Accessions
- Primary accessionG9KLM5
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, coiled coil, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 45-310 | Protein kinase | ||||
Sequence: YDVVKVIGRGAFGEVQEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFCAFQDDKYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLFEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIKQHPFF | ||||||
Domain | 313-381 | AGC-kinase C-terminal | ||||
Sequence: DQWNWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENLLLSDS | ||||||
Coiled coil | 405-965 | |||||
Sequence: LYTLEEHLSTEMQAKEELEQKCKSVNTRLEKVAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFMNLQSVLESERRDRTHGSEIINDLQGRISGLEEDLKNGKTLLAKAEMEKRQLQEKLTDLEKEKNNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLSEERTLKQKVENLLLEAEKRCSIFDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMSLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLCKELQQKKQDLQEERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDAQEQLSRLKDE | ||||||
Domain | 453-529 | REM-1 | ||||
Sequence: ALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRT | ||||||
Domain | 935-1003 | RhoBD | ||||
Sequence: TSDVANLANEKEELNNKLKDAQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEP | ||||||
Coiled coil | 1012-1057 | |||||
Sequence: VRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQI | ||||||
Domain | 1106-1305 | PH | ||||
Sequence: ESRLEGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVLDIDKLFHVRPVTQTDVYRADAKEIPRIFQILYANEGESKKEQEFPVEPVGEKSNYICHKGHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCKVYYDISTAKNLLLLANSTEEQQKWVSRLVKKIP | ||||||
Domain | 1216-1271 | Phorbol-ester/DAG-type | ||||
Sequence: GHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPC | ||||||
Region | 1301-1343 | Disordered | ||||
Sequence: VKKIPKKPPAPDPFARSSPRTSMKIQQNQSIRRPSRQLAPNKP | ||||||
Compositional bias | 1319-1343 | Polar residues | ||||
Sequence: PRTSMKIQQNQSIRRPSRQLAPNKP |
Sequence similarities
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length1,343
- Mass (Da)156,053
- Last updated2012-02-22 v1
- ChecksumA9B0684385E5043D
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: D | ||||||
Compositional bias | 1319-1343 | Polar residues | ||||
Sequence: PRTSMKIQQNQSIRRPSRQLAPNKP | ||||||
Non-terminal residue | 1343 | |||||
Sequence: P |