G9KIX1 · G9KIX1_MUSPF

Function

function

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentcell cortex
Cellular Componentcell surface
Cellular Componentciliary rootlet
Cellular Componentdendritic shaft
Cellular Componentendoplasmic reticulum membrane
Cellular ComponentGolgi membrane
Cellular Componentgrowth cone
Cellular Componentlysosomal membrane
Cellular Componentmembrane raft
Cellular Componentmitochondrial inner membrane
Cellular Componentneuromuscular junction
Cellular Componentneuronal cell body
Cellular Componentnucleus
Cellular Componentperinuclear region of cytoplasm
Cellular ComponentZ disc
Molecular Functionaspartic endopeptidase activity, intramembrane cleaving
Biological Processamyloid precursor protein catabolic process
Biological Processamyloid-beta metabolic process
Biological Processcalcium ion transport
Biological Processintracellular signal transduction
Biological Processmembrane protein ectodomain proteolysis
Biological Processnegative regulation of apoptotic process
Biological ProcessNotch receptor processing
Biological ProcessNotch signaling pathway
Biological Processprotein processing

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Presenilin
  • EC number

Organism names

Accessions

  • Primary accession
    G9KIX1

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane97-115Helical
Transmembrane148-169Helical
Transmembrane176-198Helical
Transmembrane210-228Helical
Transmembrane235-253Helical
Transmembrane259-278Helical
Transmembrane398-418Helical
Transmembrane424-443Helical

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region1-67Disordered
Compositional bias43-60Basic and acidic residues

Domain

The PAL motif is required for normal active site conformation.

Sequence similarities

Belongs to the peptidase A22A family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    456
  • Mass (Da)
    50,892
  • Last updated
    2012-02-22 v1
  • Checksum
    E189FC9F8F568D53
LPGASQGRAMLTFMASDSEEEVCDERTSLMSAESPPPRCCQEARQGLEDRESAAQWRSQDSEEDLDEDADRYMCSGVPGQPSGLEEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVAMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLFLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQLPYDPEMEEDSYDSFGEPSYPEVFEPPLPGYPGDELEEEEERGVKLGLGDFIFYSVLVGKAAATGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLY

Features

Showing features for non-terminal residue, compositional bias.

TypeIDPosition(s)Description
Non-terminal residue1
Compositional bias43-60Basic and acidic residues
Non-terminal residue456

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JP016252
EMBL· GenBank· DDBJ
AES04850.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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