G9KFT1 · G9KFT1_MUSPF
- ProteinPlatelet-derived growth factor receptor alpha
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1095 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
Catalytic activity
- L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
Features
Showing features for binding site, active site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 572 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 599-607 | ATP (UniProtKB | ChEBI) | |||
Binding site | 600-607 | ATP (UniProtKB | ChEBI) | |||
Binding site | 627 | ATP (UniProtKB | ChEBI) | |||
Binding site | 675-681 | ATP (UniProtKB | ChEBI) | |||
Active site | 824 | Proton acceptor | |||
Binding site | 828 | ATP (UniProtKB | ChEBI) | |||
Binding site | 829 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 842 | Mg2+ (UniProtKB | ChEBI) | |||
Site | 968 | Important for interaction with phosphotyrosine-binding proteins | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Cellular Component | receptor complex | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | platelet-derived growth factor alpha-receptor activity | |
Molecular Function | platelet-derived growth factor binding | |
Biological Process | chemotaxis | |
Biological Process | embryonic cranial skeleton morphogenesis | |
Biological Process | positive regulation of kinase activity | |
Biological Process | protein phosphorylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePlatelet-derived growth factor receptor alpha
- EC number
- Alternative names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Musteloidea > Mustelidae > Mustelinae > Mustela
Accessions
- Primary accessionG9KFT1
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 525-549 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-23 | ||||
Chain | PRO_5003523040 | 24-1095 | Platelet-derived growth factor receptor alpha | ||
Disulfide bond | 49↔100 | ||||
Disulfide bond | 150↔189 | ||||
Disulfide bond | 235↔290 | ||||
Disulfide bond | 435↔501 | ||||
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 1-113 | Ig-like | |||
Domain | 202-306 | Ig-like | |||
Domain | 593-960 | Protein kinase | |||
Region | 1024-1095 | Disordered | |||
Compositional bias | 1035-1050 | Basic and acidic residues | |||
Compositional bias | 1051-1066 | Polar residues | |||
Sequence similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length1,095
- Mass (Da)123,412
- Last updated2012-02-22 v1
- ChecksumD20831D6E6F73C51
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Compositional bias | 1035-1050 | Basic and acidic residues | |||
Compositional bias | 1051-1066 | Polar residues | |||
Non-terminal residue | 1095 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JP015158 EMBL· GenBank· DDBJ | AES03756.1 EMBL· GenBank· DDBJ | mRNA |