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G9GCM3 · G9GCM3_9BACT

  • Protein
    D-alanine--D-alanine ligase
  • Gene
    vanA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Cell wall formation.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 2 magnesium or manganese ions per subunit.
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site16
Binding site134ATP (UniProtKB | ChEBI)
Binding site170-172ATP (UniProtKB | ChEBI)
Active site178
Binding site178-179ATP (UniProtKB | ChEBI)
Binding site208-215ATP (UniProtKB | ChEBI)
Binding site293Mg2+ 1 (UniProtKB | ChEBI)
Binding site305-306ATP (UniProtKB | ChEBI)
Binding site306Mg2+ 2 (UniProtKB | ChEBI)
Binding site306Mg2+ 1 (UniProtKB | ChEBI)
Binding site308Mg2+ 2 (UniProtKB | ChEBI)
Active site317

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular FunctionD-alanine-D-alanine ligase activity
Molecular Functionmetal ion binding
Biological Processcell wall organization
Biological Processpeptidoglycan biosynthetic process
Biological Processregulation of cell shape

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    D-alanine--D-alanine ligase
  • EC number
  • Alternative names
    • D-Ala-D-Ala ligase
    • D-alanylalanine synthetase

Gene names

    • Name
      vanA
    • Synonyms
      ddl

Organism names

Accessions

  • Primary accession
    G9GCM3

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain138-339ATP-grasp

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    347
  • Mass (Da)
    37,378
  • Last updated
    2012-02-22 v1
  • MD5 Checksum
    2E35D1770614FD1CBF0E58716FBD75CD
MDRLKVGIVSGGCSEEHPISVKSAQEVAQHLDVEKYEPFYIGITKRGAWKLCDGGPDARWENGRCRPAVLSPDRSMRGLLVLEHGRYETIGLDVVLPVLHGKLGEDGAMQGLLELSGIPYVGCDVQSSAVCMDKRLAYIVARSAAIATPDFWTVTANQDIDADRFTYPVFVKPARSGSSFGVSKVSEEAALLRAVESARQYDSQVVIEAAVDGSEVGCAVLGNDLDLLTGEVDRISLSHGFFRIHQEIEPGSGSENSTPIVPADISPEARSLVQETAKALYRALGCSGLARVDMFLREDGSVVLNEVNTFPGMTSYSRYPRMMAAAGLPLAEVIDRMVSLALTGNGR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JN316578
EMBL· GenBank· DDBJ
AEU25611.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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