G9G9W6 · G9G9W6_CARAU
- ProteinStress-activated protein kinase JNK
- GeneJNKa
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids427 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | JUN kinase activity | |
Molecular Function | protein serine kinase activity | |
Biological Process | rhythmic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameStress-activated protein kinase JNK
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Cyprinidae > Cyprininae > Carassius
Accessions
- Primary accessionG9G9W6
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 26-321 | Protein kinase | ||||
Sequence: YQNLRPIGSGAQGIVCSAYDHNLERNVAIKKLSRPFQNQTHAKRAYRELVLMKYVNHKNIIGLLNVFTSQKTFDEFQDVYLVMELMDANLCQVIQMELDHERLSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAATGLLMTPYVVTRYYRAPEVILGMGYQANVDVWSVGCIMAEMVRGSVLFPGSDHIDQWNKVIEQLGTPSQEFMMKLNQSVRTYVENRPRYTGYSFEKLFPDVLFPADSENNKLKASQARDLLSKMLVIDASKRISVDEALRHPYI | ||||||
Region | 378-427 | Disordered | ||||
Sequence: PIGAAVINGSPQPSSSSSINDVSSMSTEPTVASDTDSSLEASAGPLSCCR | ||||||
Compositional bias | 382-419 | Polar residues | ||||
Sequence: AVINGSPQPSSSSSINDVSSMSTEPTVASDTDSSLEAS |
Sequence similarities
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length427
- Mass (Da)48,366
- Last updated2012-02-22 v1
- Checksum7ABB805E1CC54DDD
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 382-419 | Polar residues | ||||
Sequence: AVINGSPQPSSSSSINDVSSMSTEPTVASDTDSSLEAS |