G9BLS6 · G9BLS6_MYODS
- ProteinCyclic nucleotide-gated channel alpha-1
- GeneCNGA1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids502 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Pore-forming subunit of the rod cyclic nucleotide-gated channel. Mediates rod photoresponses at dim light converting transient changes in intracellular cGMP levels into electrical signals. In the dark, cGMP levels are high and keep the channel open enabling a steady inward current carried by Na+ and Ca2+ ions that leads to membrane depolarization and neurotransmitter release from synaptic terminals. Upon photon absorption cGMP levels decline leading to channel closure and membrane hyperpolarization that ultimately slows neurotransmitter release and signals the presence of light, the end point of the phototransduction cascade. Conducts cGMP- and cAMP-gated ion currents, with permeability for monovalent and divalent cations. The selectivity for Ca2+ over Na+ increases with cGMP concentrations, whereas the selectivity among monovalent ions is independent of the cGMP levels.
Catalytic activity
- Ca2+(in) = Ca2+(out)
- Cs+(in) = Cs+(out)
- K+(in) = K+(out)
- Li+(in) = Li+(out)
- NH4+(in) = NH4+(out)
- Na+(in) = Na+(out)
- Rb+(in) = Rb+(out)
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | intracellular cyclic nucleotide activated cation channel complex | |
Cellular Component | plasma membrane | |
Molecular Function | calcium channel activity | |
Molecular Function | cGMP binding | |
Molecular Function | intracellularly cAMP-activated cation channel activity | |
Molecular Function | intracellularly cGMP-activated cation channel activity | |
Molecular Function | protein-containing complex binding | |
Biological Process | visual perception |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCyclic nucleotide-gated channel alpha-1
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Chiroptera > Yangochiroptera > Vespertilionidae > Myotis
Accessions
- Primary accessionG9BLS6
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 51-75 | Helical | ||||
Sequence: YYNWLFCITLPVMYNWTLIIARACF | ||||||
Transmembrane | 189-207 | Helical | ||||
Sequence: LVMYIVIIIHWNACVYYSI | ||||||
Transmembrane | 261-283 | Helical | ||||
Sequence: YVFVVVDFLIGVLIFATIVGNIG |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-16 | Basic and acidic residues | ||||
Sequence: DDKNENKKDPEKKKKK | ||||||
Region | 1-30 | Disordered | ||||
Sequence: DDKNENKKDPEKKKKKEKDKVKKKKEEKKD | ||||||
Domain | 365-471 | Cyclic nucleotide-binding | ||||
Sequence: IFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGITQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEAL |
Sequence similarities
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length502
- Mass (Da)58,390
- Last updated2012-02-22 v1
- Checksum1E95B21F6EC7C08D
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: D | ||||||
Compositional bias | 1-16 | Basic and acidic residues | ||||
Sequence: DDKNENKKDPEKKKKK | ||||||
Non-terminal residue | 502 | |||||
Sequence: A |