G9BLS2 · G9BLS2_9CHIR

Function

function

Pore-forming subunit of the rod cyclic nucleotide-gated channel. Mediates rod photoresponses at dim light converting transient changes in intracellular cGMP levels into electrical signals. In the dark, cGMP levels are high and keep the channel open enabling a steady inward current carried by Na+ and Ca2+ ions that leads to membrane depolarization and neurotransmitter release from synaptic terminals. Upon photon absorption cGMP levels decline leading to channel closure and membrane hyperpolarization that ultimately slows neurotransmitter release and signals the presence of light, the end point of the phototransduction cascade. Conducts cGMP- and cAMP-gated ion currents, with permeability for monovalent and divalent cations. The selectivity for Ca2+ over Na+ increases with cGMP concentrations, whereas the selectivity among monovalent ions is independent of the cGMP levels.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentintracellular cyclic nucleotide activated cation channel complex
Cellular Componentplasma membrane
Molecular Functioncalcium channel activity
Molecular FunctioncGMP binding
Molecular Functionintracellularly cAMP-activated cation channel activity
Molecular Functionintracellularly cGMP-activated cation channel activity
Molecular Functionprotein-containing complex binding
Biological Processvisual perception

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cyclic nucleotide-gated channel alpha-1
  • Alternative names
    • Cyclic nucleotide-gated channel, photoreceptor
    • Rod photoreceptor cGMP-gated cation channel subunit alpha
    • cGMP-gated cation channel alpha-1

Gene names

    • Name
      CNGA1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Chiroptera > Yangochiroptera > Vespertilionidae > Tylonycteris

Accessions

  • Primary accession
    G9BLS2

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane51-71Helical
Transmembrane83-103Helical
Transmembrane189-207Helical
Transmembrane261-283Helical

Keywords

  • Cellular component

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias1-16Basic and acidic residues
Region1-33Disordered
Domain365-471Cyclic nucleotide-binding

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    502
  • Mass (Da)
    58,384
  • Last updated
    2012-02-22 v1
  • Checksum
    23E6B3FD4253B566
DDKSENKKDPEKKKKKEKDKEKKKKEGKKDKDKKEEKKKEVMIIDPSGNTYYNWLFCITLPVMYNWTLIVARACFDELQSDYLAYWLFFDYLSDVVYLLDMFVRTRTGYLEQGLLVKEELKLIEKYKSNLQFKLDVLSVIPTDLLYFKLGWNYPEIRLNRLLRISRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVYYSISKAIGFGNDTWVYPDVNDPEFGRLARKYVYSLYWSTLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEREVLKYLPDKLRAEIAISVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGITQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKGMLEEKGKQILMKDGLLDVNIANA

Features

Showing features for non-terminal residue, compositional bias.

TypeIDPosition(s)Description
Non-terminal residue1
Compositional bias1-16Basic and acidic residues
Non-terminal residue502

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HQ610165
EMBL· GenBank· DDBJ
AET43278.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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