G8YLU5 · G8YLU5_PICSO
- ProteinDNA replication licensing factor MCM3
- GenePiso0_001827
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids858 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
Catalytic activity
- ATP + H2O = ADP + phosphate + H+
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | CMG complex | |
Cellular Component | cytoplasm | |
Cellular Component | MCM complex | |
Cellular Component | nuclear pre-replicative complex | |
Cellular Component | replication fork protection complex | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | DNA replication origin binding | |
Molecular Function | single-stranded DNA binding | |
Molecular Function | single-stranded DNA helicase activity | |
Biological Process | DNA strand elongation involved in DNA replication | |
Biological Process | DNA unwinding involved in DNA replication | |
Biological Process | double-strand break repair via break-induced replication | |
Biological Process | mitotic DNA replication initiation | |
Biological Process | pre-replicative complex assembly involved in nuclear cell cycle DNA replication | |
Biological Process | premeiotic DNA replication |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDNA replication licensing factor MCM3
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Debaryomycetaceae > Millerozyma
Accessions
- Primary accessionG8YLU5
Proteomes
Subcellular Location
Interaction
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 307-513 | MCM | |||
Region | 675-745 | Disordered | |||
Compositional bias | 690-705 | Acidic residues | |||
Compositional bias | 713-727 | Polar residues | |||
Sequence similarities
Belongs to the MCM family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length858
- Mass (Da)96,277
- Last updated2012-02-22 v1
- Checksum7687A3A2156F0108
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 690-705 | Acidic residues | |||
Compositional bias | 713-727 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
FO082054 EMBL· GenBank· DDBJ | CCE89029.1 EMBL· GenBank· DDBJ | Genomic DNA |