G8YLU5 · G8YLU5_PICSO

Function

function

Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.

Catalytic activity

GO annotations

AspectTerm
Cellular ComponentCMG complex
Cellular Componentcytoplasm
Cellular ComponentMCM complex
Cellular Componentnuclear pre-replicative complex
Cellular Componentreplication fork protection complex
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionDNA replication origin binding
Molecular Functionsingle-stranded DNA binding
Molecular Functionsingle-stranded DNA helicase activity
Biological ProcessDNA strand elongation involved in DNA replication
Biological ProcessDNA unwinding involved in DNA replication
Biological Processdouble-strand break repair via break-induced replication
Biological Processmitotic DNA replication initiation
Biological Processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
Biological Processpremeiotic DNA replication

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA replication licensing factor MCM3
  • EC number

Gene names

    • Name
      Piso0_001827
    • ORF names
      GNLVRS01_PISO0F14921g

Organism names

Accessions

  • Primary accession
    G8YLU5

Proteomes

Subcellular Location

Keywords

  • Cellular component

Interaction

Subunit

Component of the MCM2-7 complex.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain307-513MCM
Region675-745Disordered
Compositional bias690-705Acidic residues
Compositional bias713-727Polar residues

Sequence similarities

Belongs to the MCM family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    858
  • Mass (Da)
    96,277
  • Last updated
    2012-02-22 v1
  • Checksum
    7687A3A2156F0108
MEDSQINEQPIDAVFGDRVRKFQEFLDRIDTDATHYRNEIKNMLMKNRYRLCVSVDELRDFDRDFWDGLMNSPADFLPACERALRDTVLTIYDPNDSRFSEIDENQQFYLSFKGSFGSHQVSPRTINSQYLSKMISIEGIVTRASLVRPKIIRSVHYAEKTSRFYAREYRDQTTSFNPISTAAIYPTEDLEGNKLTTEYGFCTYKDHQKISVQEMPELAPAGQLPRSVDVILDDDLVDLTKPGDRIQIVGVYRALGGANNNSTSFKTVVLANSVYALHTRSTGVASQEKLTDQDIRNINKLSKEKKIFEILSNSLAPSIYGSEYIKKAILLMLLGGVEKNLDNGTHLRGDINILMVGDPSTAKSQLLRFVLNTAPLAIATTGRGSSGVGLTAAVTSDKETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRVAIHEVMEQQTVTIAKAGIHTSLNARCSVIAAANPVFGQYDVHKDPHKNIALPDSLLSRFDLLFVVTDDVIPTKDRIISEHVLRMHRFIPPGLVEGEPIKEKTNLTLAVGDDSTNEKEAQEQPIFEKFNALIHSGVSASSKKSPTLLSIPFLKKYIQYSKQRVRPVLTKKASDYIVNTYSGLRNDLIDNNQRHTAPITARTLETLIRLATAHAKVRLSRTVEIKDAKVAEELLRFALFKEVTKKTRSKKQRVTPSSDTESDELDETESEEEDEEEVTPRRTTVRTRSSYRTETASRETTSEPSEETPESTEANEVQRNLDNLHIQQADLDGANGQRPLSEAPNHDNNANQLISAERYATFIRIMARVMQSSIFDNESGSAPVDQVSQTVNESVEQEDVFIQSEIEAAFARMEAENKIMIGEGKVWKI

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias690-705Acidic residues
Compositional bias713-727Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FO082054
EMBL· GenBank· DDBJ
CCE89029.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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