G8Y3R4 · G8Y3R4_PICSO

Function

function

ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.

Catalytic activity

  • Hydrolysis of proteins in presence of ATP.
    EC:3.4.21.53 (UniProtKB | ENZYME | Rhea)

Features

Showing features for binding site, active site.

110861002003004005006007008009001,000
Type
IDPosition(s)Description
Binding site541-548ATP (UniProtKB | ChEBI)
Active site962
Active site1005

GO annotations

AspectTerm
Cellular Componentmitochondrial matrix
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent peptidase activity
Molecular Functionsequence-specific DNA binding
Molecular Functionserine-type endopeptidase activity
Molecular Functionsingle-stranded DNA binding
Biological Processcellular response to oxidative stress
Biological Processchaperone-mediated protein complex assembly
Biological Processmitochondrion organization
Biological Processoxidation-dependent protein catabolic process
Biological Processprotein quality control for misfolded or incompletely synthesized proteins

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lon protease homolog, mitochondrial
  • EC number

Gene names

    • Name
      Piso0_004920
    • Synonyms
      PIM1
    • ORF names
      GNLVRS01_PISO0M03862g

Organism names

Accessions

  • Primary accession
    G8Y3R4

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homohexamer or homoheptamer. Organized in a ring with a central cavity.

Protein-protein interaction databases

Family & Domains

Features

Showing features for compositional bias, region, domain, coiled coil.

Type
IDPosition(s)Description
Compositional bias70-95Basic and acidic residues
Region70-160Disordered
Compositional bias102-116Basic and acidic residues
Compositional bias132-156Polar residues
Domain165-389Lon N-terminal
Coiled coil446-473
Compositional bias757-818Basic and acidic residues
Region757-834Disordered
Domain868-1056Lon proteolytic

Sequence similarities

Belongs to the peptidase S16 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,086
  • Mass (Da)
    120,853
  • Last updated
    2012-02-22 v1
  • MD5 Checksum
    957B9024F81BD5FC8780DF4F7F255406
MLKPRRYARVPFWMSRSSALMTIRFASRVVNHNVPLLETDSPHLQLPPSLKQSILNIQSVDHVEDVLTRYFDGESKEEEKRDKETPNKNEETEEESEIKKEEDKETDEKKDNDVKENGVGPSGPLKPISGSAGGSSPPSGNNGDDPDDSNSQLPVDPVTGLYPPLLAIPMKDRPPLPGRPFAINITDPEVIKSIYTIIEKREPYFVLFHVRNNNEADTDVISSKSSVYDIGVHCQIIRHTTPRPGVFNVLGYPLERCKLEELTTPASKKTSKKAKNDDSENFPTSYLKGHKVSYASVRPIKDEPYDKASAEVRSLVESLKTLLSKLGGKNPLEKLQIKEGTDLINDPSKFADFVGSTIHGDPKKIQEILETLNIESRLSKALELLKVELKASLIKESTIHNLSTKADEYQTRLFIKEFIKELQKRAGITESEDKRTSKFDERLKHLKLTEEAMEAYNAEKAKMESQNEHSSELGVSERYLDWLTSIPWGVYSKDTFNITHAKDILERDHYGLKDVKERILEFISMGKISGKVDGKILCLTGPPGTGKTSIAKSIAEALNRKYVRIAMGGIQDVHEVKGHRRTYVGSIPGRIISALKQAKTSNPLMLIDEIDKLDLSRGGGAASAFLEILDPEQNNSFVDNYIDLKVDLSKVLFVCTANYIGNIPGPLRDRMEIIDVPGYTNNEKVEIAKKHLIPDVSRKANLDSTHVVIPSETIAKLVEKYCRESGLRNVKKLINRIFSKASLKIVEEVEKLEGVKEPAVEADKSDKSKTEAEAEAEATSSSESKEVPKDAKSSKEGSEVRFESQETGKDKDETTIDSEDKENEAEADHADEAVKFDIPETIKLEVSPNKLKDYIGPEIYTKDRVYDTLPPGVATGLSYSTSGNGDALYIESILTHPISSGAGQPGMHLTGSLKDVMKESASIAYSFVKSCMAKKFPENRFFEVADIHVHCPDGAIPKDGPSAGISFASSLISLALNHPLPPTFAMTGEITVTGRVLPVGGLREKILGAKRYGCNVVIFPKDIENELEEIPDEVKEGVRFIPVEWYDDVYNNLFQEISEQKGNEIWKEDFATLESKKKKKKSQGNL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias70-95Basic and acidic residues
Compositional bias102-116Basic and acidic residues
Compositional bias132-156Polar residues
Compositional bias757-818Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FO082047
EMBL· GenBank· DDBJ
CCE85332.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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