G8U129 · G8U129_SULAD

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site10-15substrate
Active site70Proton acceptor
Binding site70Mg2+ (UniProtKB | ChEBI)
Binding site71substrate
Binding site151-154substrate
Binding site173substrate
Binding site178-179substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • Ordered locus names
      Sulac_0755

Organism names

Accessions

  • Primary accession
    G8U129

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    196
  • Mass (Da)
    21,726
  • Last updated
    2012-02-22 v1
  • MD5 Checksum
    12A06DA9C0823D56D299BC4579A1D63B
MNHKVVVLASHNPGKLREFAQLFQGAPFELVLWPGRDEIIAETGDTYVENARIKAHYVARQTGHWALADDSGIEVDYLGGLPGVNSAHFVSQNPWENTREILLRLMDAPPSARTARMRAVLCLASPDGAEWLAEGVVEGWILPWPRGTHGFGVDPIFSVNGRESLAEWPEAEKNAVSHRARAVQALWNIINEQGLF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP003179
EMBL· GenBank· DDBJ
AEW04262.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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