G8NTI5 · G8NTI5_GRAMM

Function

function

Catalyzes the NAD+-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.

Catalytic activity

Features

Showing features for binding site, site.

138650100150200250300350
Type
IDPosition(s)Description
Binding site123substrate
Binding site147substrate
Binding site148NAD+ (UniProtKB | ChEBI)
Binding site148NADP+ 2 (UniProtKB | ChEBI)
Binding site148NADP+ 1 (UniProtKB | ChEBI)
Binding site202NAD+ (UniProtKB | ChEBI)
Binding site202NADP+ 1 (UniProtKB | ChEBI)
Binding site202NADP+ 2 (UniProtKB | ChEBI)
Binding site202-203NAD+ (UniProtKB | ChEBI)
Binding site203NAD+ (UniProtKB | ChEBI)
Binding site203NADP+ 1 (UniProtKB | ChEBI)
Binding site203NADP+ 2 (UniProtKB | ChEBI)
Binding site222NAD+ (UniProtKB | ChEBI)
Binding site224NADP+ 1 (UniProtKB | ChEBI)
Binding site257-261NAD+ (UniProtKB | ChEBI)
Binding site259NAD+ (UniProtKB | ChEBI)
Binding site259NADP+ 1 (UniProtKB | ChEBI)
Binding site261NADP+ 1 (UniProtKB | ChEBI)
Binding site283NAD+ (UniProtKB | ChEBI)
Binding site284NAD+ (UniProtKB | ChEBI)
Binding site284NADP+ 1 (UniProtKB | ChEBI)
Binding site284NADP+ 2 (UniProtKB | ChEBI)
Site285Important for catalytic activity
Binding site309NAD+ (UniProtKB | ChEBI)
Binding site333NADP+ 1 (UniProtKB | ChEBI)
Site333Important for catalytic activity
Binding site333-336NAD+ (UniProtKB | ChEBI)
Binding site335NAD+ (UniProtKB | ChEBI)
Binding site335NADP+ 1 (UniProtKB | ChEBI)
Binding site335NADP+ 2 (UniProtKB | ChEBI)
Binding site381NAD+ (UniProtKB | ChEBI)
Binding site381NADP+ 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionformate dehydrogenase (NAD+) activity
Molecular FunctionNAD binding
Molecular Functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological Processformate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Formate dehydrogenase
  • EC number
  • Short names
    FDH
  • Alternative names
    • NAD-dependent formate dehydrogenase

Gene names

    • Ordered locus names
      AciX8_0868

Organism names

Accessions

  • Primary accession
    G8NTI5

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain72-359D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Domain156-335D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    386
  • Mass (Da)
    42,536
  • Last updated
    2012-02-22 v1
  • MD5 Checksum
    CD90EB5DC42D605FC638AF0F1793955D
MAKILCVLYDDPITGYPKSYARADVPKIDHYPGGQTAPTPKQIDFTPGELLGSVSGELGLRKYLEGLGHTLVVTSDKEGEDSVFERELPDAEIVISQPFWPAYLTPERIAKAKKLKLAVTAGIGSDHVDLEAAIKNGITVAEVTYSNSISVSEHVVMMILSLVRNYIPSYQWVIKGGWNIADCVERSYDLEAMHVGTVAAGRIGLAVLKRLKPFDVKLHYFDQHRLPESVENELGLTYHPSVEDMVKVCDVVTINAPLHPGTLDLFNDELISKMKRGAYLVNTARGKICNRDAVVRALESGQLAGYAGDVWFPQPAPKDHPWRTMPHHGMTPHISGTSLSAQARYAAGTREILECWFEERPIREEYLIVDGGKLAGTGAHSYTVSK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP003130
EMBL· GenBank· DDBJ
AEU35217.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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