G8I184 · G8I184_9HIV1

Function

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell endosome membrane
Cellular Componenthost cell plasma membrane
Cellular Componentplasma membrane
Cellular Componentviral envelope
Cellular Componentvirion membrane
Molecular Functionstructural molecule activity
Biological Processapoptotic process
Biological Processmembrane fusion involved in viral entry into host cell
Biological Processsymbiont entry into host cell
Biological Processvirion attachment to host cell

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Envelope glycoprotein gp160
  • Cleaved into 2 chains

Organism names

Accessions

  • Primary accession
    G8I184

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein
Cell membrane
; Single-pass type I membrane protein
Endosome membrane
; Peripheral membrane protein
Endosome membrane
; Single-pass type I membrane protein
Host cell membrane
; Peripheral membrane protein
Host cell membrane
; Single-pass type I membrane protein
Host endosome membrane
; Peripheral membrane protein
Host endosome membrane
; Single-pass type I membrane protein
Membrane
; Peripheral membrane protein
Membrane
; Single-pass type I membrane protein
Virion membrane
; Peripheral membrane protein
Virion membrane
; Single-pass type I membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane529-553Helical
Transmembrane696-723Helical

Keywords

PTM/Processing

Keywords

Interaction

Subunit

The mature envelope protein (Env) consists of a homotrimer of non-covalently associated gp120-gp41 heterodimers. The resulting complex protrudes from the virus surface as a spike.

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain34-528Human immunodeficiency virus 1 envelope glycoprotein Gp120
Domain548-737Retroviral envelope protein GP41-like
Region737-761Disordered
Compositional bias747-761Basic and acidic residues

Domain

The 17 amino acids long immunosuppressive region is present in many retroviral envelope proteins. Synthetic peptides derived from this relatively conserved sequence inhibit immune function in vitro and in vivo.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    874
  • Mass (Da)
    98,620
  • Last updated
    2012-01-25 v1
  • Checksum
    7E61735207534F12
MRAKEIRKNCQGLWKGGILLLGMLMICSAKEENLWVTVHLGGPGWKEATTILFCASDAKAYDTEAHNVWAHMPVYPQTLTQKKEIENVTKILLCEKLLGKQMHEDISVYGIKVLSHVQNYPTLCYVRMARLYWSQLYLAKVPVILVPIVVGTNSTNGTNNSSQENMKGEIKKCSFNITTQIGNKVKKEYALFNMLDIVGINDETGNTAGNTSYMLGNCNTTVITQACPKVSFEPIPIHFCTPAGFAILQCNEKRFKGTGPCRNVSTVQCTHGIRPVVSTQLLLNGSLAEEEVIIRSENFTDNAKTIIVQLNQSVEINCTRPNNNTRKSIHIGPGRAFYATGDIIGNIRQAHCIINKTKWINTLKQIKKKLEEQYNKTIHFKPSSGGDPEIVMHMFNCGGEFFYCNTTQLFNSTMLNDTEGSNDTNQNITLPCRIKQIITGCQEVGKPMYAPPISGIIRCISNITELIITRDGGNGNGTNNNTECFRPGGGDMRDNWRSELYKYKVVRIEPLGIAPTKAKRRVVQREKRAVGTIGAMFLGFLGAAGSTMGAASLTLTVQARQLLSGIVQQQNNLLRAIDAQQHMLQLTVWGIKQLQARVLAVESYLRDQQLLGIWGCSGKIICTTAVPWNTSWSNRSLDHIWNNMTWMQWEKEIDNYTGFIYTLLEESQNQQEQNEQELLALDKWTNLWNWFSITKWLWYIKMFIMIVGGLIGLRVVFTVISLVNRVRQGYSPLSFQTRFPAPRGPDRPEGTGEEGGERDRDTSTRLVHGFLALIWDDLRSLCIFSYHRLRDLLLIVTRIVELLGRRGWEALKYWWNLLQYWGQEIKNSAVSLLNATAIAVAEGTDRVIEVVQRIGRAILNIPRRIRQGLEIALL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias747-761Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JN692436
EMBL· GenBank· DDBJ
AET72085.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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