G7Z2A0 · G7Z2A0_AZOL4

Function

function

Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 2 Mg2+ ions per subunit.

Pathway

Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site34-36ATP (UniProtKB | ChEBI)
Binding site93-94ATP (UniProtKB | ChEBI)
Binding site127Mg2+ (UniProtKB | ChEBI)
Binding site168Mg2+ (UniProtKB | ChEBI)
Active site191
Binding site193D-ribose 5-phosphate (UniProtKB | ChEBI)
Binding site217D-ribose 5-phosphate (UniProtKB | ChEBI)
Binding site221-225D-ribose 5-phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentribose phosphate diphosphokinase complex
Molecular FunctionATP binding
Molecular Functionkinase activity
Molecular Functionmagnesium ion binding
Molecular Functionribose phosphate diphosphokinase activity
Biological Process5-phosphoribose 1-diphosphate biosynthetic process
Biological Processpurine nucleotide biosynthetic process
Biological Processribonucleoside monophosphate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribose-phosphate pyrophosphokinase
  • EC number
  • Short names
    RPPK
  • Alternative names
    • 5-phospho-D-ribosyl alpha-1-diphosphate synthase
    • Phosphoribosyl diphosphate synthase
    • Phosphoribosyl pyrophosphate synthase
      (P-Rib-PP synthase
      ; PRPP synthase
      ; PRPPase
      )

Gene names

    • Name
      prsA
    • Synonyms
      prs
    • Ordered locus names
      AZOLI_2290

Organism names

Accessions

  • Primary accession
    G7Z2A0

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homohexamer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-117Ribose-phosphate pyrophosphokinase N-terminal

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    311
  • Mass (Da)
    33,473
  • Last updated
    2012-01-25 v1
  • Checksum
    B1F3CCFD9DE8A998
MKVLAGNSNRPLAEAISTCLGVPLTKASVRRFSDMEVFVEILENVRGEDVFVVQSTSFPANDNLMELLVTIDALRRGSARRITAVIPYYGYARQDRKTGPRTPISAKLVANLITQAGANRVLTMDLHAGQIQGFFDIPTDNLMAAPVFEKDIRQSFENIGEVTIVSPDVGGVVRARALAKRLDADLAIIDKRRERAGVSEVMNIIGDANGRRCILLDDIVDSGGTLCNAAVALMEAGAKSVHAFCTHGVLSGGAVARVAVSPLEQLVTTDSIQATEAVRVSRNIRQLTIAPLLAEAIMRISEERSVSSLFS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FQ311868
EMBL· GenBank· DDBJ
CBS87508.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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