G7VVW6 · G7VVW6_PAETH

Function

function

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

167950100150200250300350400450500550600650
Type
IDPosition(s)Description
Binding site207-214ATP (UniProtKB | ChEBI)
Binding site429Zn2+ (UniProtKB | ChEBI); catalytic
Active site430
Binding site433Zn2+ (UniProtKB | ChEBI); catalytic
Binding site505Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent peptidase activity
Molecular Functionmetalloendopeptidase activity
Molecular Functionzinc ion binding
Biological Processcell division
Biological Processprotein catabolic process
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent zinc metalloprotease FtsH
  • EC number

Gene names

    • Name
      ftsH
    • Ordered locus names
      HPL003_07775

Organism names

Accessions

  • Primary accession
    G7VVW6

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Membrane

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane9-26Helical
Transmembrane114-136Helical

Keywords

Interaction

Subunit

Homohexamer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain199-338AAA+ ATPase
Region610-679Disordered
Compositional bias636-650Basic and acidic residues
Compositional bias651-679Polar residues

Sequence similarities

Belongs to the AAA ATPase family.
In the C-terminal section; belongs to the peptidase M41 family.
In the central section; belongs to the AAA ATPase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    679
  • Mass (Da)
    75,020
  • Last updated
    2012-01-25 v1
  • MD5 Checksum
    33A69339CA1767C5EFCAC5A01295056D
MNRFIRNSGFYLILFLVVVGIVQFVSNSNEASDLPRYDQLRQEVKANNISKVTVQFDGYAYLVTGAYKKQPANAKSTNFSVYVPPTDSALTELVNASETNGFEYVQKKMEGESIWLTFLTSIVPLVIMFLLFFFLFNQAQGGGGKVMNFGKSKARLYNEEKKKVTFEDVAGADEEKQELVEVVEFLKDPRKFAAVGARIPKGVLLVGPPGTGKTLLARAVAGEAGVPFFSISGSDFVEMFVGVGASRVRDLFENAKKNAPCIIFIDEIDAVGRQRGAGLGGGHDEREQTLNQLLVEMDGFGANEGIIIVAATNRPDILDPALLRPGRFDRQITVDRPDVKGREAVLFVHARNKPLTKDVKMDVIAKRTTGFTGADLENLLNEAALLAARRNRKDISMREVDEAIDRVIVGTEKRSRVISDREKRIVAYHEAGHTIIGFFLENADMVHKVTIIPRGRAGGYVIMLPKEDRMLTTKQELLDKITGLLGGRVSEELFIGEIGTGAYSDFQQATSIARSMIVEYGMSEKLGPMQFGTSQGQVFLGRDIGHEQNYSDQIAYQIDQEMNRFITESYERARELLTKHSKEVHLIAQTLLVEETLELDQIKRLIETGSLDGSKDEGEGTPENGEPVIDNIGDVRVRIQGKDDEPKNTTDQPNDIPNLQKPEDGNNSGNSGGTPPPTT

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias636-650Basic and acidic residues
Compositional bias651-679Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP003107
EMBL· GenBank· DDBJ
AET58318.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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