G7Q410 · G7Q410_9BACT

Function

function

Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

Pathway

Quinol/quinone metabolism; menaquinone biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site57[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site61[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site64[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet

GO annotations

AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Function7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity
Molecular Functioniron ion binding
Molecular Functionoxidoreductase activity, acting on X-H and Y-H to form an X-Y bond
Molecular Functiontransferase activity, transferring alkyl or aryl (other than methyl) groups
Biological Processmenaquinone biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cyclic dehypoxanthine futalosine synthase
  • EC number
  • Short names
    Cyclic DHFL synthase
  • Alternative names
    • Dehypoxanthine futalosine cyclase
      (DHFL cyclase
      )
    • Menaquinone biosynthetic enzyme MqnC

Gene names

    • Name
      mqnC
    • ORF names
      DFW101_0783

Organism names

Accessions

  • Primary accession
    G7Q410

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain43-271Radical SAM core

Sequence similarities

Belongs to the radical SAM superfamily. MqnC family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    348
  • Mass (Da)
    38,103
  • Last updated
    2012-01-25 v1
  • Checksum
    1DCBEF146706E316
MPDRAIGRISLAEARALWEDEDVFSLGKKAHAARMALHPEAVVTYIVDRNINYTNVCACGCRFCAFFRPPGHAEGYVLSREQLAAKVAETVALGGYQILLQGGMHPDLRLDFYTGMLAFLRDRFPEVAVHGFSPPEIVFLARMEGLSIAEVLAELKASGLASLPGGGAEILSDPIRGSVSPNKCPADEWIAVMAEAHKQGLRSTATMVIGLGETIEHRLEHLSRIRDLQDATGGFTAFIPWTFQPGNTALAVPEASSWEYLRTLALARLFLDNVPNIQASWVTQGPMIGQTALYFGANDFGSTMIEENVVAAAGVRFRMEEDELCRLAVKAGFEPVRRNMDYSRREGS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CM001368
EMBL· GenBank· DDBJ
EHJ46800.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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