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G7N8B1 · G7N8B1_MACMU

Function

function

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

Catalytic activity

  • Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
    EC:3.4.11.18 (UniProtKB | ENZYME | Rhea)

Cofactor

Co2+ (UniProtKB | Rhea| CHEBI:48828 )

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Fe2+ (UniProtKB | Rhea| CHEBI:29033 )

Note: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe2+-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site161substrate
Binding site178a divalent metal cation 1 (UniProtKB | ChEBI)
Binding site189a divalent metal cation 2 (UniProtKB | ChEBI); catalytic
Binding site189a divalent metal cation 1 (UniProtKB | ChEBI)
Binding site252a divalent metal cation 2 (UniProtKB | ChEBI); catalytic
Binding site259substrate
Binding site284a divalent metal cation 2 (UniProtKB | ChEBI); catalytic
Binding site315a divalent metal cation 2 (UniProtKB | ChEBI); catalytic
Binding site315a divalent metal cation 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functioninitiator methionyl aminopeptidase activity
Molecular Functionmetal ion binding
Molecular Functionmetalloaminopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Methionine aminopeptidase
  • EC number

Gene names

    • Name
      METAP1D
    • Synonyms
      MAP1D

Organism names

  • Taxonomic identifier
  • Strain
    • 17573
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Macaca

Accessions

  • Primary accession
    G7N8B1
  • Secondary accessions
    • A0A5F7ZA23

Proteomes

Organism-specific databases

Expression

Gene expression databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain97-321Peptidase M24

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    335
  • Mass (Da)
    37,143
  • Last updated
    2012-01-25 v1
  • MD5 Checksum
    B694AF73C1ACFA62E056B5C4C8450B5C
MAAPSGVHLLVRRGSHRIFSSPLNHIYLHKQSSRQQRRNFFFRRQRDISHSIVLPAAVSSAHLVPKHIKKPDYVTTGIVPDWGDSIEVKNEDQIQGLHQACQLARHVLLLAGKSLKVDMTTEEIDALVHREIISHNAYPSPLGYGGFPKSVCTSVNNVLCHGIPDSRPLQDGDIINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITNQNGLQVCPHFVGHGIGSYFHGHPEIWHHANDNDLPMEEGMAFTIEPIITEGSPEFKVLEDAWTVVSLDNQRSAQFEHTVLITSRGAQILTKLPHEA

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
F7F2S1F7F2S1_MACMUMETAP1D331
A0A1D5Q0E4A0A1D5Q0E4_MACMUMETAP1D351

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JU333797
EMBL· GenBank· DDBJ
AFE77552.1
EMBL· GenBank· DDBJ
mRNA
JV046650
EMBL· GenBank· DDBJ
AFI36721.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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