G7N441 · G7N441_MACMU
- ProteinLactosylceramide 4-alpha-galactosyltransferase
- GeneA4GALT
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids353 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
Catalytic activity
- a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = a globoside Gb3Cer (d18:1(4E)) + UDP + H+This reaction proceeds in the forward direction.
- a beta-D-Gal-(1<->1')-ceramide + UDP-alpha-D-galactose = alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer + UDP + H+This reaction proceeds in the forward direction.
Pathway
Glycolipid biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | Golgi membrane | |
Molecular Function | acetylglucosaminyltransferase activity | |
Molecular Function | galactosyltransferase activity | |
Molecular Function | lactosylceramide 4-alpha-galactosyltransferase activity | |
Molecular Function | toxic substance binding | |
Biological Process | globoside biosynthetic process | |
Biological Process | plasma membrane organization | |
Biological Process | protein O-linked glycosylation |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLactosylceramide 4-alpha-galactosyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Macaca
Accessions
- Primary accessionG7N441
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Golgi apparatus membrane ; Single-pass type II membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 20-42 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 222-349 | Alpha 1,4-glycosyltransferase | |||
Sequence similarities
Belongs to the glycosyltransferase 32 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length353
- Mass (Da)40,397
- Last updated2012-01-25 v1
- MD5 ChecksumDAF051521E0B624935E2DD04161B65BF
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JU473743 EMBL· GenBank· DDBJ | AFH30547.1 EMBL· GenBank· DDBJ | mRNA |